PAK6

Gene Symbol	PAK6
Entrez Gene	56924
Alt Symbol	PAK5
Species	Human
Gene Type	protein-coding
Description	p21 protein (Cdc42/Rac)-activated kinase 6
Other Description	p21(CDKN1A)-activated kinase 6|serine/threonine-protein kinase PAK 6
Swissprots	G5E9R2 B3KYB0 A8K2G2 Q9NQU5
Accessions	CAC39969 CAK32184 CBX51397 EAW92395 EAW92396 EAW92397 EAW92398 EAW92399 EAW92400 EAW92401 Q9NQU5 AF276893 AAF82800 AJ236915 CAC18720 AK026592 AK131522 BAG54772 AK290227 BAF82916 AK315813 BAF98704 AK315817 BAF98708 BC035596 AAH35596 DA191028 DA229537 DA414215 DQ892109 ABM83035 DQ895303 ABM86229 HY128655 NM_001128628 NP_001122100 NM_001128629 NP_001122101 NM_001276717 NP_001263646 NM_001276718 NP_001263647 NM_020168 NP_064553
Function	Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}.
Subcellular Location	Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
Tissue Specificity	Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. {ECO:0000269|PubMed:11278661, ECO:0000269|PubMed:11773441}.
Top Pathways	Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PAK6 full length protein - ab89757 from Abcam Category Protein Prices $302.00, $352.00 Sizes 5 µg, 10 µg Source Baculovirus infected sf9 cells Species Human

Active human PAK6 protein fragment - ab95321 from Abcam Category Protein Prices $761.00 Sizes 10 µg Source E. coli Species Human

Human PAK6 (phospho S165) peptide - ab42722 from Abcam Category Peptide Species Human

Human PAK6 peptide - ab42721 from Abcam Category Peptide Species Human

PAK6 Antibody Blocking Peptide - LS-E1458 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAK6 Antibody Blocking Peptide - LS-E30006 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PAK6 Antibody Blocking Peptide - LS-E9377 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PAK6 Antibody Blocking Peptide - LS-E29205 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PAK6 Antibody Blocking Peptide - LS-E29206 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

PAK6 Antibody Blocking Peptide - LS-E29294 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human PAK6 Protein - H00056924-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

PAK6 Recombinant Protein - P4744 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

PAK6 Blocking Peptide - NBP1-76632PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

PAK6-Antibody-Center-Blocking-peptide - BP12164c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PAK6-Antibody-Blocking-Peptide - BP7931a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PAK5/PAK7 Blocking Peptide - 33R-10570 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

PAK6 Blocking Peptide - 33R-10569 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

PAK6 Blocking Peptide - 33R-11001 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

PAK6 Blocking Peptide - abx063919 from Abbexa Category Peptide Species Human, Mouse, Rat

PAK6 - H00056924-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

PAK6 - P4744 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

PAK6 - P5386 from Acris Antibodies Category Protein Prices $670.00 Sizes 10 µg Species Human

PAK6 - P5791 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

PAK6 Control Peptide - AP30644CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

PAK6 Peptide - 3073P from ProSci Category Peptide Species Human

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