PAK6

Gene Symbol PAK6
Entrez Gene 56924
Alt Symbol PAK5
Species Human
Gene Type protein-coding
Description p21 protein (Cdc42/Rac)-activated kinase 6
Other Description p21(CDKN1A)-activated kinase 6|serine/threonine-protein kinase PAK 6
Swissprots G5E9R2 B3KYB0 A8K2G2 Q9NQU5
Accessions CAC39969 CAK32184 CBX51397 EAW92395 EAW92396 EAW92397 EAW92398 EAW92399 EAW92400 EAW92401 Q9NQU5 AF276893 AAF82800 AJ236915 CAC18720 AK026592 AK131522 BAG54772 AK290227 BAF82916 AK315813 BAF98704 AK315817 BAF98708 BC035596 AAH35596 DA191028 DA229537 DA414215 DQ892109 ABM83035 DQ895303 ABM86229 HY128655 NM_001128628 NP_001122100 NM_001128629 NP_001122101 NM_001276717 NP_001263646 NM_001276718 NP_001263647 NM_020168 NP_064553
Function Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}.
Subcellular Location Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
Tissue Specificity Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. {ECO:0000269|PubMed:11278661, ECO:0000269|PubMed:11773441}.
Top Pathways Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, ErbB signaling pathway

PAK6 (H-300) - sc-32857 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PAK6 (H-300): sc-32857. Western blot analysis of PAK6 expression in non-transfected: sc-117752 (A) and human PAK6 transfected: sc-115034 (B) 293T whole cell lysates.

PAK6 (H-6) - sc-393075 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PAK6 (H-6): sc-393075. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skin tissue showing cytoplasmic and nuclear staining of keratinocytes, fibroblasts, Langerhans cells and melanocytes.

PAK6 (K-17) - sc-25976 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PAK6 (K-17): sc-25976. Western blot analysis of PAK6 expression in non-transfected: sc-117752 (A) and human PAK6 transfected: sc-158808 (B) 293T whole cell lysates.

PAK6 (N-20) - sc-25975 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PAK6 (N-20): sc-25975. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic and nuclear staining of exocrine glandular cells and Islets of Langerhans.

PAK6 (C-2) - sc-393102 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PAK6 (C-2): sc-393102. Western blot analysis of PAK6 expression in non-transfected: sc-110760 (A) and human PAK6 transfected: sc-158808 (B) 293 whole cell lysates.

Anti-PAK6 (phospho S165) antibody - ab41432 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Lanes 1 - 4 : Anti-PAK6 antibody (ab41431) at 1/1000 dilutionLanes 5 - 8 : Anti-PAK6 (phospho S165) antibody (ab41432) at 1/1000 dilutionLane 1 : Human PAK6 recombinant protein phosphorylated by ERK2Lane 2 : Human PAK6 recombinant protein phosphorylated by ERK2; blot exposed to lambda phosphatase before probing Lane 3 : Human PAK6 recombinant protein phosphorylated by ERK2 with non-specific peptide Lane 4 : Human PAK6 recombinant protein phosphorylated by ERK2 with PAK6 N-terminal peptide (ab41431 immunogen) Lane 5 : Human PAK6 recombinant protein phosphorylated by ERK2Lane 6 : Human PAK6 recombinant protein phosphorylated by ERK2; blot exposed to lambda phosphatase before probingLane 7 : Human PAK6 recombinant protein phosphorylated by ERK2 with phospho-S165-PAK6 peptide (ab41432 immunogen) Lane 8 : Human PAK6 recombinant protein phosphorylated by ERK2 with non-specific phospho-serine peptide

Anti-PAK6 antibody - ab62511 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-PAK6 antibody (ab62511) at 1 µg/mlLane 2 : Anti-PAK6 antibody (ab62511) at 2 µg/mlLane 3 : Anti-PAK6 antibody (ab62511) at 4 µg/mlLane 1 : Raji lysateLane 2 : Raji lysateLane 3 : Raji lysateLysates/proteins at 15 µg per lane.

Anti-PAK6 antibody - ab41431 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PAK6 antibody (ab41431) at 1/1000 dilutionLane 1 : Human PAK6 recombinant protein phosphorylated by ERK2Lane 2 : Human PAK6 recombinant protein phosphorylated by ERK2; blot exposed to lambda phosphatase before probingLane 3 : Human PAK6 recombinant protein phosphorylated by ERK2 with non-specific peptide Lane 4 : Human PAK6 recombinant protein phosphorylated by ERK2 with PAK6 N-terminal peptide (ab41431 immunogen)

Anti-PAK6 antibody - ab115608 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab115608, at 10µg/ml, staining PAK6 in Formalin-fixed, Paraffin-embedded Human Testis tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-PAK6 antibody - N-terminal - ab189766 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PAK6 antibody - N-terminal (ab189766) at 1/1000 dilutionLane 1 : Mouse thymus total cell extractLane 2 : HeLa total cell extract

Anti-PAK6 Antibody - LS-C2823 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK6 Antibody - LS-C9452 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK6 Antibody (aa151-200, DY650) - LS-C140740 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PAK6 Antibody (aa151-200, Biotin) - LS-C140739 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PAK6 Antibody (aa151-200, DY488) - LS-C140756 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PAK6 Antibody (aa151-200, HRP) - LS-C140757 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PAK6 Antibody (aa151-200, DY550) - LS-C140758 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PAK6 Antibody - LS-C147039 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PAK6 Antibody (aa275-305, AP) - LS-C265510 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK6 Antibody (aa275-305, APC) - LS-C265511 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK6 Antibody (aa275-305, FITC) - LS-C265512 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK6 Antibody (aa275-305, PE) - LS-C265513 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK6 Antibody (Linker Domain) IHC-plus™ - LS-A7962 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PAK6 antibody LS-A7962 IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-PAK6 Antibody (aa131-146, APC) - LS-C280529 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PAK6 Antibody (aa131-146, AP) - LS-C280530 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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