PAK6

Gene Symbol	PAK6
Entrez Gene	56924
Alt Symbol	PAK5
Species	Human
Gene Type	protein-coding
Description	p21 protein (Cdc42/Rac)-activated kinase 6
Other Description	p21(CDKN1A)-activated kinase 6|serine/threonine-protein kinase PAK 6
Swissprots	G5E9R2 B3KYB0 A8K2G2 Q9NQU5
Accessions	CAC39969 CAK32184 CBX51397 EAW92395 EAW92396 EAW92397 EAW92398 EAW92399 EAW92400 EAW92401 Q9NQU5 AF276893 AAF82800 AJ236915 CAC18720 AK026592 AK131522 BAG54772 AK290227 BAF82916 AK315813 BAF98704 AK315817 BAF98708 BC035596 AAH35596 DA191028 DA229537 DA414215 DQ892109 ABM83035 DQ895303 ABM86229 HY128655 NM_001128628 NP_001122100 NM_001128629 NP_001122101 NM_001276717 NP_001263646 NM_001276718 NP_001263647 NM_020168 NP_064553
Function	Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:20054820}.
Subcellular Location	Cytoplasm. Nucleus. Note=Cotranslocates into nucleus with AR in response to androgen induction.
Tissue Specificity	Selectively expressed in brain and testis, with lower levels in multiple tissues including prostate and breast. {ECO:0000269|PubMed:11278661, ECO:0000269|PubMed:11773441}.
Top Pathways	Axon guidance, Focal adhesion, T cell receptor signaling pathway, Renal cell carcinoma, ErbB signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PAK6 293 Cell Lysate - 402402 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

PAK6 Overexpression Lysate (Native) - NBL1-14083 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

PAK6 Overexpression Lysate (Native) - NBP2-09484 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

PAK6 (h): 293T Lysate - sc-115034 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

PAK6 (h4): 293 Lysate - sc-158808 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

PAK6 Over-expression Lysate Product - GWB-684B48 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

PAK6 Overexpression Lysate (Native) - NBP2-09483 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

PAK6 Overexpression Lysate (Denatured) - H00056924-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human PAK6 Knockdown Stable Cell Line - CSC-DC011265 from Creative biogene Category Cell Line Species Human

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