MAP3K13

Gene Symbol	MAP3K13
Entrez Gene	9175
Alt Symbol	LZK, MEKK13, MLK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase 13
Other Description	leucine zipper-bearing kinase|mixed lineage kinase
Swissprots	Q15450 Q05BY6 B4DLE3 O43283 B4DMV2 D3DNU1 B4DZJ4 B2R6U2 Q2NKN3
Accessions	EAW78224 EAW78225 O43283 AB001872 BAA24817 AI690808 AK123148 AK296961 BAG59505 AK297646 BAG60014 AK302951 BAG64106 AK312714 BAG35589 BC015996 BC026249 BC031677 AAH31677 BC036593 BC111726 AAI11727 BQ432918 Z25428 CAA80915 XM_011513310 XP_011511612 NM_001242314 NP_001229243 NM_001242317 NP_001229246 NR_038322 NM_004721 NP_004712
Function	Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9353328}. Membrane {ECO:0000269|PubMed:9353328}; Peripheral membrane protein {ECO:0000269|PubMed:9353328}.
Tissue Specificity	Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas. {ECO:0000269|PubMed:9353328}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

LZK (E-18) - sc-49295 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

LZK (K-19) - sc-49297 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

LZK (N-17) - sc-49298 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

LZK (1-RY22) - sc-134380 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-MAP3K13 antibody - ab113034 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K13 antibody - ab172226 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAP3K13 antibody - ab67894 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-MAP3K13 antibody [810CT26.6.1.1] - C-terminal - ab188376 from Abcam Prices $376.00 Sizes 400 µl Host Mouse Clonality Monoclonal Clone 810CT26.6.1.1

Anti-MAP3K13 antibody - C-terminal - ab199165 from Abcam Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K13 / LZK Antibody (C-Terminus, AP) - LS-C262560 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K13 / LZK Antibody (C-Terminus, APC) - LS-C262564 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K13 / LZK Antibody (Phe183) - LS-C191921 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAP3K13 / LZK Antibody (C-Terminus, Biotin) - LS-C262565 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K13 / LZK Antibody (C-Terminus, FITC) - LS-C262566 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K13 / LZK Antibody (C-Terminus, Azide-free, HRP) - LS-C262567 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K13 / LZK Antibody (aa134-183) - LS-C292151 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAP3K13 / LZK Antibody - LS-C308876 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-MAP3K13 / LZK Antibody (C-Terminus, PE) - LS-C262568 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K13 / LZK Antibody - LS-C310926 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAP3K13 / LZK Antibody (aa711-810) - LS-C308878 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MAP3K13 / LZK Antibody (aa151-200) - LS-C118677 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAP3K13 / LZK Antibody (C-Terminus) - LS-C329801 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K13 / LZK Antibody (Ser869) - LS-C163999 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-MAP3K13 / LZK Antibody (N-Terminus, clone 810CT26.6.1.1) - LS-C344108 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Mouse Clonality Monoclonal Clone 810CT26.6.1.1

MAP3K13 Antibody - NBP1-81272 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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