MAP3K13

Gene Symbol MAP3K13
Entrez Gene 9175
Alt Symbol LZK, MEKK13, MLK
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase kinase kinase 13
Other Description leucine zipper-bearing kinase|mixed lineage kinase
Swissprots Q15450 Q05BY6 B4DLE3 O43283 B4DMV2 D3DNU1 B4DZJ4 B2R6U2 Q2NKN3
Accessions EAW78224 EAW78225 O43283 AB001872 BAA24817 AI690808 AK123148 AK296961 BAG59505 AK297646 BAG60014 AK302951 BAG64106 AK312714 BAG35589 BC015996 BC026249 BC031677 AAH31677 BC036593 BC111726 AAI11727 BQ432918 Z25428 CAA80915 XM_011513310 XP_011511612 NM_001242314 NP_001229243 NM_001242317 NP_001229246 NR_038322 NM_004721 NP_004712
Function Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:9353328}. Membrane {ECO:0000269|PubMed:9353328}; Peripheral membrane protein {ECO:0000269|PubMed:9353328}.
Tissue Specificity Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas. {ECO:0000269|PubMed:9353328}.
Top Pathways MAPK signaling pathway

LZK CRISPR/Cas9 KO Plasmid (h) - sc-417523 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZK HDR Plasmid (h) - sc-417523-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZK Double Nickase Plasmid (h) - sc-417523-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZK Double Nickase Plasmid (h2) - sc-417523-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZK CRISPR Activation Plasmid (h) - sc-417523-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZK CRISPR Activation Plasmid (h2) - sc-417523-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZK Lentiviral Activation Particles (h) - sc-417523-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZK Lentiviral Activation Particles (h2) - sc-417523-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LZK siRNA (h) - sc-60976 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LZK shRNA Plasmid (h) - sc-60976-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LZK shRNA (h) Lentiviral Particles - sc-60976-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MAP3K13 RNAi - H00009175-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU017211 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1133 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1134 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1132 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN12990 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12990 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03228 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03228

MAP3K13 siRNA (Human) - CRH6071 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MAP3K13 (NM_004721.4) - SHH337655 from Creative biogene

Category siRNA
Species Reactivities Human

MAP3K13 shRNA Plasmid (Human) - CHH6071 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MAP3K13 miRNA 3'UTR clone - MiUTR3H-07204 from Creative biogene

Species Reactivities Human
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