| Gene Symbol |
MAP3K13
|
| Entrez Gene |
9175
|
| Alt Symbol |
LZK, MEKK13, MLK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase kinase 13
|
| Other Description |
leucine zipper-bearing kinase|mixed lineage kinase
|
| Swissprots |
Q15450 Q05BY6 B4DLE3 O43283 B4DMV2 D3DNU1 B4DZJ4 B2R6U2 Q2NKN3
|
| Accessions |
EAW78224 EAW78225 O43283 AB001872 BAA24817 AI690808 AK123148 AK296961 BAG59505 AK297646 BAG60014 AK302951 BAG64106 AK312714 BAG35589 BC015996 BC026249 BC031677 AAH31677 BC036593 BC111726 AAI11727 BQ432918 Z25428 CAA80915 XM_011513310 XP_011511612 NM_001242314 NP_001229243 NM_001242317 NP_001229246 NR_038322 NM_004721 NP_004712
|
| Function |
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9353328}. Membrane {ECO:0000269|PubMed:9353328}; Peripheral membrane protein {ECO:0000269|PubMed:9353328}.
|
| Tissue Specificity |
Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas. {ECO:0000269|PubMed:9353328}.
|
| Top Pathways |
MAPK signaling pathway
|