MAP3K13

Gene Symbol	MAP3K13
Entrez Gene	9175
Alt Symbol	LZK, MEKK13, MLK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase 13
Other Description	leucine zipper-bearing kinase|mixed lineage kinase
Swissprots	Q15450 Q05BY6 B4DLE3 O43283 B4DMV2 D3DNU1 B4DZJ4 B2R6U2 Q2NKN3
Accessions	EAW78224 EAW78225 O43283 AB001872 BAA24817 AI690808 AK123148 AK296961 BAG59505 AK297646 BAG60014 AK302951 BAG64106 AK312714 BAG35589 BC015996 BC026249 BC031677 AAH31677 BC036593 BC111726 AAI11727 BQ432918 Z25428 CAA80915 XM_011513310 XP_011511612 NM_001242314 NP_001229243 NM_001242317 NP_001229246 NR_038322 NM_004721 NP_004712
Function	Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:9353328}. Membrane {ECO:0000269|PubMed:9353328}; Peripheral membrane protein {ECO:0000269|PubMed:9353328}.
Tissue Specificity	Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas. {ECO:0000269|PubMed:9353328}.
Top Pathways	MAPK signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MAP3K13 gene - orb91445 from Biorbyt Prices $519.00 Sizes 10 μg Species Human

Human-MAP3K13-cDNA-Clone - DC09660 from Abgent, a WuXi AppTec company Prices $885.60 Sizes 10 µg Species Human Accession BC111726

MAP3K13 - MBS1277125 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC111726

Human MAP3K13 Gene cDNA clone plasmid - HG10634-M from Sino Biological Species Human

Human MAP3K13 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10634-ANG from Sino Biological Species Human

Human MAP3K13 Gene ORF cDNA clone expression plasmid, N-His tag - HG10634-NH from Sino Biological Species Human

Human MAP3K13 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10634-NF from Sino Biological Species Human

Human MAP3K13 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10634-CY from Sino Biological Species Human

Human MAP3K13 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10634-NM from Sino Biological Species Human

Human MAP3K13 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10634-CF from Sino Biological Species Human

Human MAP3K13 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10634-CM from Sino Biological Species Human

Human MAP3K13 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10634-NY from Sino Biological Species Human

Human MAP3K13 Gene ORF cDNA clone expression plasmid, C-His tag - HG10634-CH from Sino Biological Species Human

Human MAP3K13 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10634-ACR from Sino Biological Species Human

Human MAP3K13 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10634-ANR from Sino Biological Species Human

Human MAP3K13 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10634-ACG from Sino Biological Species Human

Human MAP3K13 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10634-M-F from Sino Biological Species Human

Human MAP3K13 Gene ORF cDNA clone expression plasmid - HG10634-UT from Sino Biological Species Human

Human MAP3K13 ORF clone (NM_001242317.1) - CDCL130223 from Creative biogene Species Human

Human MAP3K13 ORF Clone (BC111726) - CDCS409743 from Creative biogene Species Human Accession O43283

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