ACVRL1

Gene Symbol ACVRL1
Entrez Gene 94
Alt Symbol ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I
Species Human
Gene Type protein-coding
Description activin A receptor type II-like 1
Other Description TGF-B superfamily receptor type I|activin A receptor, type II-like kinase 1|serine/threonine-protein kinase receptor R3
Swissprots P37023 A6NGA8
Accessions AAB61900 CAA02404 EAW58211 EAW58212 EAW58213 EAW58214 P37023 AK056725 AK298493 BAG60701 AK300619 BAG62312 AK303331 BAG64396 BC042637 AAH42637 DN999570 HM161905 ADJ79922 HM161906 ADJ79923 JF432428 ADZ15645 L17075 AAA16160 Z22533 CAA80255 XM_005269235 XP_005269292 XM_011539008 XP_011537310 NM_000020 NP_000011 NM_001077401 NP_001070869
Function Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. {ECO:0000269|PubMed:22718755, ECO:0000269|PubMed:22799562}.
Subcellular Location Membrane; Single-pass type I membrane protein.

ALK-1 (H-150) - sc-28976 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ALK-1 (H-150): sc-28976. Western blot analysis of ALK-1 expression in human platelet extract.

ALK-1 (C-20) - sc-19547 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ALK-1 (C-20): sc-19547. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic and membrane staining of glandular cells.

ALK-1 (D-20) - sc-19546 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ALK-1 (D-20): sc-19546. Immunofluorescence staining of methanol-fixed JAR cells showing membrane localization.

ALK-1 (MM0015-8G33) - sc-101555 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-ACVRL1 antibody - ab68703 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ACVRL1 was immunoprecipitated using 0.5mg K562 whole cell extract, 5µg of Rabbit polyclonal to ACVRL1 and 50µl of protein G magnetic beads (+). No antibody was added to the control (-).The antibody was incubated under agitation with Protein G beads for 10min, K562 whole cell extract lysate diluted in RIPA buffer was added to each sample and incubated for a further 10min under agitation.Proteins were eluted by addition of 40µl SDS loading buffer and incubated for 10min at 70°C; 10µl of each sample was separated on a SDS PAGE gel, transferred to a nitrocellulose membrane, blocked with 5% BSA and probed with ab68703.Secondary: Mouse monoclonal [SB62a] Secondary Antibody to Rabbit IgG light chain (HRP) (ab99697).Band: 62kDa; ACVRL1, non specific - as present in control (lane 2); We are confident this was due to slight lane contamination and the band seen in the IP lane is our target of interest.

Anti-ACVRL1 antibody - ab74039 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of ACVRL1 in paraffin embedded human breast carcinoma tissue using ab74039 at a 1/50 dilution. Left image: untreated.Right image: treated with immunizing peptide.

Anti-ACVRL1 antibody - ab37807 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ACVRL1 antibody (ab37807) at 1/100 dilution + mouse heart tissue lysate

Anti-ACVRL1 antibody - ab131132 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of Formalin-Fixed, Paraffin-Embedded Human Brain, Cerebellum tissue labelling Activin Receptor Like Kinase 1 with ab131132 at 5 µg/ml.

Anti-ACVRL1 antibody - ab93595 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ACVRL1 antibody (ab93595) at 1/200 dilution + Human fetal heart lysate

Anti-ACVRL1 antibody - ab10179 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-ACVRL1 antibody (ab10179) at 2 µg/ml + MCF7 lysate at 35 µgdeveloped using the ECL technique

Anti-ACVRL1 antibody [EPR4074] - ab108207 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4074
All lanes : Anti-ACVRL1 antibody [EPR4074] (ab108207) at 1/1000 dilutionLane 1 : JAR cell lysateLane 2 : Daudi cell lysateLane 3 : Jurkat cell lysateLysates/proteins at 10 µg per lane.

Anti-ACVRL1 antibody [MM0015-8G33] - ab51870 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0015-8G33
ab51870 at 1/50 dilution staining ACVRL1 in Human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

Anti-ACVRL1 antibody - N-terminal - ab190663 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ACVRL1 antibody - N-terminal (ab190663) at 1/500 dilution + MCF7 cell extract at 30 µg

Anti-ACVRL1 Antibody (aa11-44) - LS-C344211 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical of paraffin-embedded H.small intestine section using ACVRL1 Antibody. Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.

Anti-ACVRL1 Antibody (aa38-68) - LS-C97153 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-ACVR2 / ACVR2A Antibody IHC-plus™ - LS-B4067 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-ALK-1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4067 concentration 20 ug/ml.

Anti-ACVRL1 Antibody (aa488-504) - LS-C3250 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ACVRL1 Antibody (aa491-503) - LS-C54444 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-ACVRL1 Antibody (Extracellular Domain, clone 1B03) - LS-C194779 from LifeSpan Bioscience

Prices $830.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 1B03

Anti-ACVRL1 Antibody (Extracellular Domain, clone 8G33) - LS-C194778 from LifeSpan Bioscience

Prices $830.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8G33

Anti-ACVRL1 Antibody (aa46-76, Biotin) - LS-C250813 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACVRL1 Antibody (aa38-68, APC) - LS-C250812 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACVRL1 Antibody (aa38-68, FITC) - LS-C250814 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACVRL1 Antibody (aa38-68, Azide-free, HRP) - LS-C250815 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACVRL1 Antibody (aa38-68, PE) - LS-C250816 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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