Gene Symbol | ACVRL1 |
---|---|
Entrez Gene | 94 |
Alt Symbol | ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I |
Species | Human |
Gene Type | protein-coding |
Description | activin A receptor type II-like 1 |
Other Description | TGF-B superfamily receptor type I|activin A receptor, type II-like kinase 1|serine/threonine-protein kinase receptor R3 |
Swissprots | P37023 A6NGA8 |
Accessions | AAB61900 CAA02404 EAW58211 EAW58212 EAW58213 EAW58214 P37023 AK056725 AK298493 BAG60701 AK300619 BAG62312 AK303331 BAG64396 BC042637 AAH42637 DN999570 HM161905 ADJ79922 HM161906 ADJ79923 JF432428 ADZ15645 L17075 AAA16160 Z22533 CAA80255 XM_005269235 XP_005269292 XM_011539008 XP_011537310 NM_000020 NP_000011 NM_001077401 NP_001070869 |
Function | Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. {ECO:0000269|PubMed:22718755, ECO:0000269|PubMed:22799562}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |