ACVRL1

Gene Symbol	ACVRL1
Entrez Gene	94
Alt Symbol	ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I
Species	Human
Gene Type	protein-coding
Description	activin A receptor type II-like 1
Other Description	TGF-B superfamily receptor type I|activin A receptor, type II-like kinase 1|serine/threonine-protein kinase receptor R3
Swissprots	P37023 A6NGA8
Accessions	AAB61900 CAA02404 EAW58211 EAW58212 EAW58213 EAW58214 P37023 AK056725 AK298493 BAG60701 AK300619 BAG62312 AK303331 BAG64396 BC042637 AAH42637 DN999570 HM161905 ADJ79922 HM161906 ADJ79923 JF432428 ADZ15645 L17075 AAA16160 Z22533 CAA80255 XM_005269235 XP_005269292 XM_011539008 XP_011537310 NM_000020 NP_000011 NM_001077401 NP_001070869
Function	Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. {ECO:0000269|PubMed:22718755, ECO:0000269|PubMed:22799562}.
Subcellular Location	Membrane; Single-pass type I membrane protein.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ALK-1 CRISPR/Cas9 KO Plasmid (h) - sc-400728 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ALK-1 HDR Plasmid (h) - sc-400728-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ALK-1 Double Nickase Plasmid (h) - sc-400728-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ALK-1 Double Nickase Plasmid (h2) - sc-400728-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ALK-1 CRISPR Activation Plasmid (h) - sc-400728-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ALK-1 CRISPR Activation Plasmid (h2) - sc-400728-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ALK-1 Lentiviral Activation Particles (h) - sc-400728-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ALK-1 Lentiviral Activation Particles (h2) - sc-400728-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ALK-1 siRNA (h) - sc-40212 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ALK-1 shRNA Plasmid (h) - sc-40212-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ALK-1 shRNA (h) Lentiviral Particles - sc-40212-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU058271 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0046 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0047 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0048 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1597 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1597 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11553 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11553

ACVRL1 siRNA (Human) - CRH0060 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ALK-1 RNAi - H00000094-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ACVRL1 - MBS8210864 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ALK-1 CRISPR/Cas9 KO Plasmid (h2) - sc-400728-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ALK-1 HDR Plasmid (h2) - sc-400728-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human ACVRL1 (NM_000020.2) - SHH231274 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human ACVRL1(NM_000020.2) - SHG037603 from Creative biogene Category siRNA Species Reactivities Human

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