Gene Symbol | ACVRL1 |
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Entrez Gene | 94 |
Alt Symbol | ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I |
Species | Human |
Gene Type | protein-coding |
Description | activin A receptor type II-like 1 |
Other Description | TGF-B superfamily receptor type I|activin A receptor, type II-like kinase 1|serine/threonine-protein kinase receptor R3 |
Swissprots | P37023 A6NGA8 |
Accessions | AAB61900 CAA02404 EAW58211 EAW58212 EAW58213 EAW58214 P37023 AK056725 AK298493 BAG60701 AK300619 BAG62312 AK303331 BAG64396 BC042637 AAH42637 DN999570 HM161905 ADJ79922 HM161906 ADJ79923 JF432428 ADZ15645 L17075 AAA16160 Z22533 CAA80255 XM_005269235 XP_005269292 XM_011539008 XP_011537310 NM_000020 NP_000011 NM_001077401 NP_001070869 |
Function | Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. {ECO:0000269|PubMed:22718755, ECO:0000269|PubMed:22799562}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
ACVRL1-Over-expression-Lysate - LY10661a from Abgent, a WuXi AppTec company
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ACVRL1 overexpression lysate - LY400003 from Acris Antibodies
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ACVRL1 overexpression lysate - LY421410 from Acris Antibodies
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ACVRL1 293 Cell Lysate - 400102 from ABBIOTEC
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ACVRL1 293 Cell Lysate - 409508 from ABBIOTEC
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ALK-1 Overexpression Lysate (Native) - NBL1-07298 from Novus Biologicals
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ALK-1 Overexpression Lysate (Native) - NBL1-07299 from Novus Biologicals
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ACVRL1 Over-expression Lysate Product - GWB-203B9E from Genway Biotech
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ACVRL1 Over-expression Lysate Product - GWB-175052 from Genway Biotech
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Cynomolgus ALK-1 / ACVRL1 HEK293 Cell Lysate (WB positive control) - 90060-C08HL-300 from Sino Biological
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Cynomolgus ALK-1 / ACVRL1 HEK293 Cell Lysate (WB positive control) - 90060-C02HL-300 from Sino Biological
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Human ALK-1 / ACVRL1 HEK293 Cell Lysate (WB positive control) - 10066-H08HL-300 from Sino Biological
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Human ALK-1 / ACVRL1 HEK293 Cell Lysate (WB positive control) - 10066-H02HL-300 from Sino Biological
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Human ALK-1 Human Cells Transfected Lysate (positive control) (denatured) - orb173204 from Biorbyt
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Human ALK-1 pair set - orb233537 from Biorbyt
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Human ALK-1 Human Cells Transfected Lysate (positive control) (denatured) - orb172759 from Biorbyt
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Panoply™ Human ACVRL1 Knockdown Stable Cell Line - CSC-DC000219 from Creative biogene
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