Gene Symbol |
F2R
|
Entrez Gene |
2149
|
Alt Symbol |
CF2R, HTR, PAR-1, PAR1, TR
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
coagulation factor II (thrombin) receptor
|
Other Description |
protease-activated receptor 1|proteinase-activated receptor 1
|
Swissprots |
Q9BUN4 Q96RF7 P25116 Q53XV0
|
Accessions |
AAC25993 AAC50740 AAK69768 EAW95779 EAW95780 EAW95781 P25116 AK297131 BAG59635 AK308169 AK314202 AY771596 AAX11426 BC002464 AAH02464 BC016059 BC051909 AAH51909 BT007279 AAP35943 DQ895099 ABM86025 EU176315 ABW03766 M62424 AAA36743 S76625 AAD14229 NM_001992 NP_001983
|
Function |
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. {ECO:0000269|PubMed:10079109}.
|
Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
Tissue Specificity |
Platelets and vascular endothelial cells.
|
Top Pathways |
Rap1 signaling pathway, cAMP signaling pathway, PI3K-Akt signaling pathway, Endocytosis, Calcium signaling pathway
|