Gene Symbol | F2R |
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Entrez Gene | 2149 |
Alt Symbol | CF2R, HTR, PAR-1, PAR1, TR |
Species | Human |
Gene Type | protein-coding |
Description | coagulation factor II (thrombin) receptor |
Other Description | protease-activated receptor 1|proteinase-activated receptor 1 |
Swissprots | Q9BUN4 Q96RF7 P25116 Q53XV0 |
Accessions | AAC25993 AAC50740 AAK69768 EAW95779 EAW95780 EAW95781 P25116 AK297131 BAG59635 AK308169 AK314202 AY771596 AAX11426 BC002464 AAH02464 BC016059 BC051909 AAH51909 BT007279 AAP35943 DQ895099 ABM86025 EU176315 ABW03766 M62424 AAA36743 S76625 AAD14229 NM_001992 NP_001983 |
Function | High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. {ECO:0000269|PubMed:10079109}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Platelets and vascular endothelial cells. |
Top Pathways | Rap1 signaling pathway, cAMP signaling pathway, PI3K-Akt signaling pathway, Endocytosis, Calcium signaling pathway |
Human Thrombin Receptor protein fragment - ab114346 from Abcam
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F2R / Thrombin Receptor / PAR1 Antibody Blocking Peptide - LS-E5487 from LifeSpan Bioscience
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F2R / Thrombin Receptor / PAR1 Antibody Blocking Peptide - LS-E21985 from LifeSpan Bioscience
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F2R / Thrombin Receptor / PAR1 Antibody Blocking Peptide - LS-E28576 from LifeSpan Bioscience
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F2R / Thrombin Receptor / PAR1 Antibody Blocking Peptide - LS-E28580 from LifeSpan Bioscience
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F2R / Thrombin Receptor / PAR1 Antibody Blocking Peptide - LS-E18552 from LifeSpan Bioscience
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F2R / Thrombin Receptor / PAR1 Antibody Blocking Peptide - LS-E27028 from LifeSpan Bioscience
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MARK2 Antibody Blocking Peptide - LS-E9417 from LifeSpan Bioscience
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MARK2 Antibody Blocking Peptide - LS-E26659 from LifeSpan Bioscience
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Recombinant Human PAR1/Thrombin Receptor Protein - H00002149-Q01 from Novus Biologicals
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PAR1/Thrombin Receptor Peptide - NBP2-11249 from Novus Biologicals
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Recombinant Human PAR1/Thrombin Receptor Protein - H00002149-G01 from Novus Biologicals
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F2R-Antibody-N-term-Blocking-Peptide - BP18006a from Abgent, a WuXi AppTec company
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Thrombin Receptor blocking peptide - GTX88425-PEP from GeneTex
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MARK2 blocking peptide - GTX88790-PEP from GeneTex
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F2R peptide - orb217269 from Biorbyt
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F2R Blocking Peptide - 33R-10057 from Fitzgerald
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PAR1 Blocking Peptide - abx062112 from Abbexa
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PAR1 Blocking Peptide - abx062600 from Abbexa
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Thrombin Receptor Peptide - AC21-1852-P from Abcore
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Thrombin receptor / F2R - H00002149-G01 from Acris Antibodies
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Thrombin receptor / F2R - H00002149-Q01-10 from Acris Antibodies
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Thrombin receptor / F2R - H00002149-Q01-25 from Acris Antibodies
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PAR1 Peptide - 46-994P from ProSci
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F2R fusion protein - ag8435 from Proteintech Group
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