Gene Symbol | F2R |
---|---|
Entrez Gene | 2149 |
Alt Symbol | CF2R, HTR, PAR-1, PAR1, TR |
Species | Human |
Gene Type | protein-coding |
Description | coagulation factor II (thrombin) receptor |
Other Description | protease-activated receptor 1|proteinase-activated receptor 1 |
Swissprots | Q9BUN4 Q96RF7 P25116 Q53XV0 |
Accessions | AAC25993 AAC50740 AAK69768 EAW95779 EAW95780 EAW95781 P25116 AK297131 BAG59635 AK308169 AK314202 AY771596 AAX11426 BC002464 AAH02464 BC016059 BC051909 AAH51909 BT007279 AAP35943 DQ895099 ABM86025 EU176315 ABW03766 M62424 AAA36743 S76625 AAD14229 NM_001992 NP_001983 |
Function | High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development. {ECO:0000269|PubMed:10079109}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Platelets and vascular endothelial cells. |
Top Pathways | Rap1 signaling pathway, cAMP signaling pathway, PI3K-Akt signaling pathway, Endocytosis, Calcium signaling pathway |