| Gene Symbol |
UGT1A4
|
| Entrez Gene |
54657
|
| Alt Symbol |
HUG-BR2, UDPGT, UDPGT 1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
UDP glucuronosyltransferase 1 family, polypeptide A4
|
| Other Description |
UDP glycosyltransferase 1 family, polypeptide A4|UDP-glucuronosyltransferase 1-4|UDP-glucuronosyltransferase 1-D|UDP-glucuronosyltransferase 1A4|bilirubin UDP-glucuronosyltransferase isozyme 2|bilirubin-specific UDPGT isozyme 2
|
| Swissprots |
B2R937 B8K288 P22310 Q5DT00
|
| Accessions |
AAA61249 AAG30422 AAL73503 AAL73504 AAL73505 AAY32626 AAY32627 AAY32628 AAY32629 ABE01866 ABE01867 ABE01868 ABE01869 ABE01870 ABE01871 ABE01872 ABE01873 ABE01874 ABE01875 ABE01876 ABE01877 EAW71061 P22310 AK313623 BAG36384 AY435139 AAR95640 BC121036 AAI21037 BC131623 AAI31624 BC139784 AAI39785 DQ364249 ABC96773 M57951 AAA63196 NM_007120 NP_009051
|
| Function |
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 2 but not isoform 1 is expressed in esophagus. Not expressed in skin. {ECO:0000269|PubMed:1339448, ECO:0000269|PubMed:18004212}.
|
| Top Pathways |
Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450
|
![Western Blot: UGT1A4 Overexpression Lysate (Adult Normal) [NBP2-07528] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for UGT1A4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1682_UGT1A4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07528-img0001.jpg)