UGT1A4

Gene Symbol	UGT1A4
Entrez Gene	54657
Alt Symbol	HUG-BR2, UDPGT, UDPGT 1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D
Species	Human
Gene Type	protein-coding
Description	UDP glucuronosyltransferase 1 family, polypeptide A4
Other Description	UDP glycosyltransferase 1 family, polypeptide A4|UDP-glucuronosyltransferase 1-4|UDP-glucuronosyltransferase 1-D|UDP-glucuronosyltransferase 1A4|bilirubin UDP-glucuronosyltransferase isozyme 2|bilirubin-specific UDPGT isozyme 2
Swissprots	B2R937 B8K288 P22310 Q5DT00
Accessions	AAA61249 AAG30422 AAL73503 AAL73504 AAL73505 AAY32626 AAY32627 AAY32628 AAY32629 ABE01866 ABE01867 ABE01868 ABE01869 ABE01870 ABE01871 ABE01872 ABE01873 ABE01874 ABE01875 ABE01876 ABE01877 EAW71061 P22310 AK313623 BAG36384 AY435139 AAR95640 BC121036 AAI21037 BC131623 AAI31624 BC139784 AAI39785 DQ364249 ABC96773 M57951 AAA63196 NM_007120 NP_009051
Function	UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). {ECO:0000250}.
Subcellular Location	Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity	Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 2 but not isoform 1 is expressed in esophagus. Not expressed in skin. {ECO:0000269|PubMed:1339448, ECO:0000269|PubMed:18004212}.
Top Pathways	Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

UGT1A4 - MBS1265949 from MyBioSource Species Human Accession BC139784

Human UGT1A4 cDNA clone(NM_007120.2) - CDFH020825 from Creative Biomart Species Human Accession NM_007120.2

Human UGT1A4 ORF clone(NM_007120.2) - CDCL186680 from Creative Biomart Species Human Accession NM_007120.2

human UGT1A4 ORF clone - CDCH097980 from Creative Biomart Species Human Accession NM_007120

human UGT1A4 ORF clone - CDCH097981 from Creative Biomart Species Human Accession NM_007120

Human UGT1A4 ORF Clone(NM_007120.2) - CDCR294443 from Creative Biomart Species Human Accession NM_007120.2

Human UGT1A4 ORF Clone(NM_007120.2) - CDCR294444 from Creative Biomart Species Human Accession NM_007120.2

Human UGT1A4 ORF Clone(NM_007120.2) - CDCR294445 from Creative Biomart Species Human Accession NM_007120.2

Human UGT1A4 Gene cDNA Clone (full-length ORF Clone) - HG13315-G from Sino Biological Species Human Accession NM_007120.2

Human UGT1A4 Gene ORF cDNA clone expression plasmid - HG13315-UT from Sino Biological Species Human

Human UGT1A4 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13315-CY from Sino Biological Species Human

Human UGT1A4 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13315-NF from Sino Biological Species Human

Human UGT1A4 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13315-NM from Sino Biological Species Human

Human UGT1A4 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13315-CF from Sino Biological Species Human

Human UGT1A4 Gene ORF cDNA clone expression plasmid, N-His tag - HG13315-NH from Sino Biological Species Human

Human UGT1A4 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13315-CM from Sino Biological Species Human

Human UGT1A4 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13315-NY from Sino Biological Species Human

Human UGT1A4 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13315-ACR from Sino Biological Species Human

Human UGT1A4 Gene ORF cDNA clone expression plasmid, C-His tag - HG13315-CH from Sino Biological Species Human

Human UGT1A4 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13315-ACG from Sino Biological Species Human

Human UGT1A4 ORF clone(NM_007120.2) - CDCL186680 from Creative biogene Species Human

Human UGT1A4 ORF Clone (BC139784) - CDCS413078 from Creative biogene Species Human Accession P22310

Human UGT1A4 cDNA Clone(NM_007120.2) - CDFH020825 from Creative biogene Species Human

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