UGT1A4

Gene Symbol UGT1A4
Entrez Gene 54657
Alt Symbol HUG-BR2, UDPGT, UDPGT 1-4, UGT-1D, UGT1-04, UGT1.4, UGT1D
Species Human
Gene Type protein-coding
Description UDP glucuronosyltransferase 1 family, polypeptide A4
Other Description UDP glycosyltransferase 1 family, polypeptide A4|UDP-glucuronosyltransferase 1-4|UDP-glucuronosyltransferase 1-D|UDP-glucuronosyltransferase 1A4|bilirubin UDP-glucuronosyltransferase isozyme 2|bilirubin-specific UDPGT isozyme 2
Swissprots B2R937 B8K288 P22310 Q5DT00
Accessions AAA61249 AAG30422 AAL73503 AAL73504 AAL73505 AAY32626 AAY32627 AAY32628 AAY32629 ABE01866 ABE01867 ABE01868 ABE01869 ABE01870 ABE01871 ABE01872 ABE01873 ABE01874 ABE01875 ABE01876 ABE01877 EAW71061 P22310 AK313623 BAG36384 AY435139 AAR95640 BC121036 AAI21037 BC131623 AAI31624 BC139784 AAI39785 DQ364249 ABC96773 M57951 AAA63196 NM_007120 NP_009051
Function UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX- alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity). {ECO:0000250}.
Subcellular Location Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity Isoform 1 and isoform 2 are expressed in liver, kidney, colon and small intestine. Isoform 2 but not isoform 1 is expressed in esophagus. Not expressed in skin. {ECO:0000269|PubMed:1339448, ECO:0000269|PubMed:18004212}.
Top Pathways Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450

UGT1A4 CRISPR/Cas9 KO Plasmid (h) - sc-402659 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A4 HDR Plasmid (h) - sc-402659-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A4 Double Nickase Plasmid (h) - sc-402659-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A4 Double Nickase Plasmid (h2) - sc-402659-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A4 CRISPR Activation Plasmid (h) - sc-402659-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A4 CRISPR Activation Plasmid (h2) - sc-402659-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A4 Lentiviral Activation Particles (h) - sc-402659-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A4 Lentiviral Activation Particles (h2) - sc-402659-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UGT1A4 siRNA (h) - sc-44472 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UGT1A4 shRNA Plasmid (h) - sc-44472-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UGT1A4 shRNA (h) Lentiviral Particles - sc-44472-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU222991 from Sigma-Aldrich

Category siRNA
Prices $140.00, $140.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22459 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22459 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

UGT1A4 siRNA (Human) - CRJ0164 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UGT1A4 - MBS829466 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human UGT1A4 (NM_007120.2) - SHH440080 from Creative biogene

Category siRNA
Species Reactivities Human

UGT1A4 shRNA Plasmid (Human) - CHJ0164 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UGT1A4 miRNA 3'UTR clone - MiUTR1H-10991 from Creative biogene

Species Reactivities Human
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