| Gene Symbol |
SUSD4
|
| Entrez Gene |
55061
|
| Alt Symbol |
PRO222
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sushi domain containing 4
|
| Other Description |
YHGM196|sushi domain-containing protein 4
|
| Swissprots |
Q9NWG0 Q9BSR0 Q5VX71 Q6UX62 D3DTB9
|
| Accessions |
EAW93257 EAW93258 EAW93259 EAW93260 EAW93261 Q5VX71 AK000914 BAA91421 AK096265 BAG53242 AK295553 BAH12105 AK296923 BAH12455 AY358495 AAQ88859 BC004888 AAH04888 BF446433 DA125047 EF560748 ABQ59058 XM_005273169 XP_005273226 XM_005273172 XP_005273229 XM_006711408 XP_006711471 XM_011509685 XP_011507987 XM_011509686 XP_011507988 XM_011509687 XP_011507989 NM_001037175 NP_001032252 NM_017982 NP_060452
|
| Function |
Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. {ECO:0000269|PubMed:23482636}.
|
| Subcellular Location |
Isoform 1: Membrane {ECO:0000305}; Single- pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Isoform 3 is the predominant isoform in all tissues except cortex, cerebellum, kidney, and breast. Isoform 1 is found primarily in the esophagus and the brain. {ECO:0000269|PubMed:23482636}.
|