Gene Symbol | SUSD4 |
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Entrez Gene | 55061 |
Alt Symbol | PRO222 |
Species | Human |
Gene Type | protein-coding |
Description | sushi domain containing 4 |
Other Description | YHGM196|sushi domain-containing protein 4 |
Swissprots | Q9NWG0 Q9BSR0 Q5VX71 Q6UX62 D3DTB9 |
Accessions | EAW93257 EAW93258 EAW93259 EAW93260 EAW93261 Q5VX71 AK000914 BAA91421 AK096265 BAG53242 AK295553 BAH12105 AK296923 BAH12455 AY358495 AAQ88859 BC004888 AAH04888 BF446433 DA125047 EF560748 ABQ59058 XM_005273169 XP_005273226 XM_005273172 XP_005273229 XM_006711408 XP_006711471 XM_011509685 XP_011507987 XM_011509686 XP_011507988 XM_011509687 XP_011507989 NM_001037175 NP_001032252 NM_017982 NP_060452 |
Function | Acts as complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. {ECO:0000269|PubMed:23482636}. |
Subcellular Location | Isoform 1: Membrane {ECO:0000305}; Single- pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Isoform 3 is the predominant isoform in all tissues except cortex, cerebellum, kidney, and breast. Isoform 1 is found primarily in the esophagus and the brain. {ECO:0000269|PubMed:23482636}. |
SUSD4 CRISPR/Cas9 KO Plasmid (h) - sc-409989 from Santa Cruz Biotechnology
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SUSD4 HDR Plasmid (h) - sc-409989-HDR from Santa Cruz Biotechnology
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SUSD4 Double Nickase Plasmid (h) - sc-409989-NIC from Santa Cruz Biotechnology
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SUSD4 Double Nickase Plasmid (h2) - sc-409989-NIC-2 from Santa Cruz Biotechnology
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SUSD4 CRISPR Activation Plasmid (h) - sc-409989-ACT from Santa Cruz Biotechnology
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SUSD4 CRISPR Activation Plasmid (h2) - sc-409989-ACT-2 from Santa Cruz Biotechnology
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SUSD4 Lentiviral Activation Particles (h) - sc-409989-LAC from Santa Cruz Biotechnology
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SUSD4 Lentiviral Activation Particles (h2) - sc-409989-LAC-2 from Santa Cruz Biotechnology
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SUSD4 siRNA (h) - sc-88469 from Santa Cruz Biotechnology
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SUSD4 shRNA Plasmid (h) - sc-88469-SH from Santa Cruz Biotechnology
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SUSD4 shRNA (h) Lentiviral Particles - sc-88469-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN20855 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20855 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09539 from Sigma-Aldrich
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SUSD4 siRNA (Human) - CRJ0437 from Cohesion Biosciences
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SUSD4 - MBS8200552 from MyBioSource
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shRNA set against Human SUSD4 (NM_017982.3) - SHH421160 from Creative biogene
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shRNA set against Human SUSD4(NM_017982.3) - SHL048700 from Creative biogene
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shRNA set against Human SUSD4(NM_001037175.2) - SHL048824 from Creative biogene
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Human SUSD4 siRNA - orb270938 from Biorbyt
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SUSD4 shRNA Plasmid (Human) - CHJ0437 from Cohesion Biosciences
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SUSD4 miRNA 3'UTR clone - MiUTR1H-10083 from Creative biogene
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SUSD4 miRNA 3'UTR clone - MiUTR1H-10084 from Creative biogene
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