ENPP6

Gene Symbol ENPP6
Entrez Gene 133121
Alt Symbol NPP6
Species Human
Gene Type protein-coding
Description ectonucleotide pyrophosphatase/phosphodiesterase 6
Other Description B830047L21Rik|E-NPP 6|GPC-Cpde|NPP-6|choline-specific glycerophosphodiester phosphodiesterase|ectonucleotide pyrophosphatase/phosphodiesterase family member 6|glycerophosphocholine cholinephosphodiesterase
Swissprots Q96M57 Q4W5Q1 Q6UWR7
Accessions AAY40908 EAX04683 Q6UWR7 AK021943 AK057370 BAB71455 AK308585 AY358676 AAQ89039 BC035035 AAH35035 NM_153343 NP_699174
Function Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'- monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid. {ECO:0000250, ECO:0000269|PubMed:15788404}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:15788404}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:15788404}. Note=A small amount of the protein may be found in the extracellular milieu.
Tissue Specificity Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level). {ECO:0000269|PubMed:15788404}.
Top Pathways Ether lipid metabolism

NPP6 (F-8) - sc-373890 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NPP6 (F-8): sc-373890. Western blot analysis of NPP6 expression in mouse brain tissue extract (A) and Caki-1 whole cell lysate (B).

NPP6 (G-9) - sc-373900 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NPP6 (G-9): sc-373900. Western blot analysis of NPP6 expression in mouse brain tissue extract.

NPP6 (D-14) - sc-161955 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NPP6 (D-14): sc-161955. Western blot analysis of NPP6 expression in mouse brain tissue extract.

Anti-ENPP6 antibody - ab128587 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-ENPP6 antibody (ab128587) at 1/1000 dilution + K562 cell lysate

Anti-ENPP6 antibody - ab70710 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-ENPP6 antibody (ab70710) at 1/500 dilutionLane 1 : ENPP6 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-ENPP6 Antibody (aa170-197, AP) - LS-C256710 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ENPP6 Antibody (aa170-197, APC) - LS-C256711 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ENPP6 Antibody (aa170-197, FITC) - LS-C256712 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ENPP6 Antibody (aa170-197, Azide-free, HRP) - LS-C256715 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ENPP6 Antibody - LS-C155726 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: MCF-7 10% SDS PAGE ENPP6 antibody diluted at 1:1000

Anti-ENPP6 Antibody (aa170-197, PE) - LS-C256716 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ENPP6 Antibody - LS-C307922 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-ENPP6 Antibody (aa170-197, Biotin) - LS-C256713 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ENPP6 Antibody (aa177-207) - LS-C321118 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ENPP6 Antibody (aa359-408) - LS-C102528 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ENPP6 antibody LS-C102528 Western blot of 721_B cell lysate.

Anti-ENPP6 Antibody (aa170-197) - LS-C167767 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ENPP6 Antibody IHC of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-ENPP6 Antibody (aa25-195) - LS-C179000 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ENPP6 Antibody - NBP1-57954 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

ENPP6 Antibody - NBP1-82710 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: ENPP6 Antibody [NBP1-82710] - Staining of human kidney shows moderate cytoplasmic positivity in cells in tubules.

ENPP6 Antibody - NBP2-16340 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ENPP6 Antibody [NBP2-16340] - Sample (30 ug of whole cell lysate) A: MCF-7 10% SDS PAGE gel, diluted at 1:1000.

ENPP6 Antibody - H00133121-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

ENPP6 Polyclonal Antibody - bs-13076R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
MCF-7 Cell lysates probed with ENPP6 Polyclonal Antibody, unconjugated (bs-13076R) at 1:300 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.

ENPP6 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13076R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ENPP6 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13076R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ENPP6 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13076R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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