| Gene Symbol |
ENPP6
|
| Entrez Gene |
133121
|
| Alt Symbol |
NPP6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ectonucleotide pyrophosphatase/phosphodiesterase 6
|
| Other Description |
B830047L21Rik|E-NPP 6|GPC-Cpde|NPP-6|choline-specific glycerophosphodiester phosphodiesterase|ectonucleotide pyrophosphatase/phosphodiesterase family member 6|glycerophosphocholine cholinephosphodiesterase
|
| Swissprots |
Q96M57 Q4W5Q1 Q6UWR7
|
| Accessions |
AAY40908 EAX04683 Q6UWR7 AK021943 AK057370 BAB71455 AK308585 AY358676 AAQ89039 BC035035 AAH35035 NM_153343 NP_699174
|
| Function |
Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'- monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid. {ECO:0000250, ECO:0000269|PubMed:15788404}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15788404}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:15788404}. Note=A small amount of the protein may be found in the extracellular milieu.
|
| Tissue Specificity |
Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level). {ECO:0000269|PubMed:15788404}.
|
| Top Pathways |
Ether lipid metabolism
|