ENPP6

Gene Symbol	ENPP6
Entrez Gene	133121
Alt Symbol	NPP6
Species	Human
Gene Type	protein-coding
Description	ectonucleotide pyrophosphatase/phosphodiesterase 6
Other Description	B830047L21Rik|E-NPP 6|GPC-Cpde|NPP-6|choline-specific glycerophosphodiester phosphodiesterase|ectonucleotide pyrophosphatase/phosphodiesterase family member 6|glycerophosphocholine cholinephosphodiesterase
Swissprots	Q96M57 Q4W5Q1 Q6UWR7
Accessions	AAY40908 EAX04683 Q6UWR7 AK021943 AK057370 BAB71455 AK308585 AY358676 AAQ89039 BC035035 AAH35035 NM_153343 NP_699174
Function	Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'- monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid. {ECO:0000250, ECO:0000269|PubMed:15788404}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:15788404}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:15788404}. Note=A small amount of the protein may be found in the extracellular milieu.
Tissue Specificity	Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level). {ECO:0000269|PubMed:15788404}.
Top Pathways	Ether lipid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ENPP6 full length protein - ab132813 from Abcam Category Protein Source Wheat germ Species Human

Human ENPP6 protein fragment - ab127072 from Abcam Category Protein Source E. coli Species Human

ENPP6 Antibody Blocking Peptide - LS-E7772 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ENPP6 Antibody Blocking Peptide - LS-E19175 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ENPP6 Recombinant Protein - H00133121-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

ENPP6-Antibody-Center-Blocking-peptide - BP5216c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human ENPP-6, CF - 8489-EN-020 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Arg23-Ser419, with a C-terminal 10-His tag

ENPP6 Blocking Peptide - 33R-2561 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ENPP6 - H00133121-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

ENPP6 fusion protein - Ag3339 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human ENPP6, GST-tagged - ENPP6-12463H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Ectonucleotide pyrophosphatase/phosphodiesterase family member - CSB-YP740915HU CSB-EP740915HU CSB-BP740915HU CSB-MP740915HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human ENPP-6 Protein, CF - 8489-EN from R&D Systems Category Protein Prices $329.00 Sizes 20 µg Source Chinese Hamster Ovary cell line, CHO-derived Arg23-Ser419, with a C-terminal 10-His tag Species Human

ENPP6 - TP306360 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ENPP6 Recombinant Protein Antigen - NBP1-82710PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E.coli Species Human

ENPP6 Peptide, Human - M34GP04950H from Creative Peptides Category Peptide Source Synthetic. Species Human

Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 (ENPP6), Recombinant Protein - MBS1288603 from MyBioSource Category Protein Prices $1,170.00, $1,170.00, $1,395.00, $1,395.00, $1,870.00, $1,870.00, $2,335.00, $2,335.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Orangutan

Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 (ENPP6), Recombinant Protein - MBS1461237 from MyBioSource Category Protein Prices $1,170.00, $1,170.00, $1,400.00, $1,400.00, $1,875.00, $1,875.00, $2,340.00, $2,340.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human ENPP-6 Protein, CF - 8489-EN from Novus Biologicals Category Protein Prices $329.00 Sizes 20 µg Species Human

Search more