| Gene Symbol | ENPP6 |
|---|---|
| Entrez Gene | 133121 |
| Alt Symbol | NPP6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ectonucleotide pyrophosphatase/phosphodiesterase 6 |
| Other Description | B830047L21Rik|E-NPP 6|GPC-Cpde|NPP-6|choline-specific glycerophosphodiester phosphodiesterase|ectonucleotide pyrophosphatase/phosphodiesterase family member 6|glycerophosphocholine cholinephosphodiesterase |
| Swissprots | Q96M57 Q4W5Q1 Q6UWR7 |
| Accessions | AAY40908 EAX04683 Q6UWR7 AK021943 AK057370 BAB71455 AK308585 AY358676 AAQ89039 BC035035 AAH35035 NM_153343 NP_699174 |
| Function | Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'- monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid. {ECO:0000250, ECO:0000269|PubMed:15788404}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:15788404}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:15788404}. Note=A small amount of the protein may be found in the extracellular milieu. |
| Tissue Specificity | Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level). {ECO:0000269|PubMed:15788404}. |
| Top Pathways | Ether lipid metabolism |
NPP6 CRISPR/Cas9 KO Plasmid (h) - sc-409036 from Santa Cruz Biotechnology
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NPP6 HDR Plasmid (h) - sc-409036-HDR from Santa Cruz Biotechnology
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NPP6 Double Nickase Plasmid (h) - sc-409036-NIC from Santa Cruz Biotechnology
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NPP6 Double Nickase Plasmid (h2) - sc-409036-NIC-2 from Santa Cruz Biotechnology
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NPP6 CRISPR Activation Plasmid (h) - sc-409036-ACT from Santa Cruz Biotechnology
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NPP6 CRISPR Activation Plasmid (h2) - sc-409036-ACT-2 from Santa Cruz Biotechnology
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NPP6 Lentiviral Activation Particles (h) - sc-409036-LAC from Santa Cruz Biotechnology
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NPP6 Lentiviral Activation Particles (h2) - sc-409036-LAC-2 from Santa Cruz Biotechnology
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NPP6 siRNA (h) - sc-89237 from Santa Cruz Biotechnology
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NPP6 shRNA Plasmid (h) - sc-89237-SH from Santa Cruz Biotechnology
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NPP6 shRNA (h) Lentiviral Particles - sc-89237-V from Santa Cruz Biotechnology
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MISSION® Human Phosphatase - SIHP0176 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0177 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0175 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7885 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7885 from Sigma-Aldrich
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ENPP6 siRNA (Human) - CRJ5111 from Cohesion Biosciences
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ENPP6 - MBS8215358 from MyBioSource
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shRNA set against Human ENPP6 (NM_153343.3) - SHH285973 from Creative biogene
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Human ENPP6 siRNA - orb275612 from Biorbyt
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ENPP6 shRNA Plasmid (Human) - CHJ5111 from Cohesion Biosciences
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ENPP6 miRNA 3'UTR clone - MiUTR4H-TG03088 from Creative biogene
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