| Gene Symbol |
CRACR2A
|
| Entrez Gene |
84766
|
| Alt Symbol |
EFCAB4B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium release activated channel regulator 2A
|
| Other Description |
CRAC channel regulator 2A|CRAC regulator 2A|Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A|EF-hand calcium binding domain 4B|EF-hand calcium-binding domain-containing protein 4B|calcium release-activated calcium channel regulator 2A|calcium release-activated channel regulator 2A
|
| Swissprots |
Q9BSW2 B4E1X0 B9EK63
|
| Accessions |
EAW88858 EAW88859 EAW88860 Q9BSW2 AK057608 AK091124 AK304017 BAG64932 BC004524 AAH04524 BC150643 AAI50644 BU632650 BU634271 CR627161 DB214079 JF432156 ADZ15373 XM_006719021 XP_006719084 XM_011521034 XP_011519336 XM_011521035 XP_011519337 XM_011521036 XP_011519338 XM_011521037 XP_011519339 XM_011521038 XP_011519340 NM_001144959 NM_001144958 NP_001138430 NM_032680 NP_116069
|
| Function |
Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {ECO:0000269|PubMed:20418871}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:20418871}.
|