CRACR2A

Gene Symbol CRACR2A
Entrez Gene 84766
Alt Symbol EFCAB4B
Species Human
Gene Type protein-coding
Description calcium release activated channel regulator 2A
Other Description CRAC channel regulator 2A|CRAC regulator 2A|Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A|EF-hand calcium binding domain 4B|EF-hand calcium-binding domain-containing protein 4B|calcium release-activated calcium channel regulator 2A|calcium release-activated channel regulator 2A
Swissprots Q9BSW2 B4E1X0 B9EK63
Accessions EAW88858 EAW88859 EAW88860 Q9BSW2 AK057608 AK091124 AK304017 BAG64932 BC004524 AAH04524 BC150643 AAI50644 BU632650 BU634271 CR627161 DB214079 JF432156 ADZ15373 XM_006719021 XP_006719084 XM_011521034 XP_011519336 XM_011521035 XP_011519337 XM_011521036 XP_011519338 XM_011521037 XP_011519339 XM_011521038 XP_011519340 NM_001144959 NM_001144958 NP_001138430 NM_032680 NP_116069
Function Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {ECO:0000269|PubMed:20418871}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:20418871}.

EF-CAB4B CRISPR/Cas9 KO Plasmid (h) - sc-413699 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-CAB4B HDR Plasmid (h) - sc-413699-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-CAB4B Double Nickase Plasmid (h) - sc-413699-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-CAB4B Double Nickase Plasmid (h2) - sc-413699-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-CAB4B CRISPR Activation Plasmid (h) - sc-413699-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-CAB4B CRISPR Activation Plasmid (h2) - sc-413699-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-CAB4B Lentiviral Activation Particles (h) - sc-413699-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-CAB4B Lentiviral Activation Particles (h2) - sc-413699-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-CAB4B siRNA (h) - sc-96150 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EF-CAB4B shRNA Plasmid (h) - sc-96150-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EF-CAB4B shRNA (h) Lentiviral Particles - sc-96150-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EFCAB4B RNAi - H00084766-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU134401 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7680 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7680 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04970 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04970

EFCAB4B siRNA (Human) - CRJ3614 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EFCAB4B - MBS8211938 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EFCAB4B (NM_032680.3) - SHH283449 from Creative biogene

Category siRNA
Species Reactivities Human

Human EFCAB4B siRNA - orb274115 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EFCAB4B shRNA Plasmid (Human) - CHJ3614 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EFCAB4B miRNA 3'UTR clone - MiUTR4H-TG02974 from Creative biogene

Species Reactivities Human
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