CRACR2A

Gene Symbol	CRACR2A
Entrez Gene	84766
Alt Symbol	EFCAB4B
Species	Human
Gene Type	protein-coding
Description	calcium release activated channel regulator 2A
Other Description	CRAC channel regulator 2A\|CRAC regulator 2A\|Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A\|EF-hand calcium binding domain 4B\|EF-hand calcium-binding domain-containing protein 4B\|calcium release-activated calcium channel regulator 2A\|calcium release-activated channel regulator 2A
Swissprots	Q9BSW2 B4E1X0 B9EK63
Accessions	EAW88858 EAW88859 EAW88860 Q9BSW2 AK057608 AK091124 AK304017 BAG64932 BC004524 AAH04524 BC150643 AAI50644 BU632650 BU634271 CR627161 DB214079 JF432156 ADZ15373 XM_006719021 XP_006719084 XM_011521034 XP_011519336 XM_011521035 XP_011519337 XM_011521036 XP_011519338 XM_011521037 XP_011519339 XM_011521038 XP_011519340 NM_001144959 NM_001144958 NP_001138430 NM_032680 NP_116069
Function	Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {ECO:0000269\|PubMed:20418871}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:20418871}.

EF-CAB4B (D-15) - sc-167721 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

EF-CAB4B (E-14) - sc-167722 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-EFCAB4B antibody - ab105418 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunofluorescence of EFCAB4B in Human kidney tissue with ab105418 at 20 ug/mL.

Anti-EFCAB4B antibody - ab69667 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-EFCAB4B antibody (ab69667) at 1/500 dilutionLane 1 : EFCAB4B transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-EFCAB4B antibody - ab98039 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EFCAB4B antibody (ab98039) at 1 µg/ml + NCI-H226 Cell Lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 50000

Anti-EFCAB4B antibody - ab98040 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EFCAB4B antibody (ab98040) at 1 µg/ml + NCI-H226 Cell Lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-EFCAB4B antibody - N-terminal - ab173705 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-EFCAB4B antibody - N-terminal (ab173705) at 1/100 dilution + 293 cell line lysate at 35 µg

Anti-EFCAB4B Antibody (aa47-74, AP) - LS-C234873 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-EFCAB4B Antibody (aa47-74, APC) - LS-C234874 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-EFCAB4B Antibody (aa47-74, Biotin) - LS-C234875 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-EFCAB4B Antibody (aa47-74, FITC) - LS-C234876 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-EFCAB4B Antibody (aa47-74, PE) - LS-C234878 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-EFCAB4B Antibody - LS-C307907 from LifeSpan Bioscience

Host	Mouse
Clonality	Polyclonal

Anti-EFCAB4B Antibody (aa47-74) - LS-C321026 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-EFCAB4B Antibody (aa47-74, Azide-free, HRP) - LS-C249893 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-EFCAB4B Antibody (aa71-120) - LS-C107684 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

EFCAB4B antibody LS-C107684 Western blot of NCI-H226 cell lysate.

Anti-EFCAB4B Antibody (aa215-264) - LS-C107685 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

EFCAB4B antibody LS-C107685 Western blot of NCI-H226 cell lysate.

Anti-EFCAB4B Antibody (aa47-74) - LS-C159509 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

EFCAB4B Antibody western blot of 293 cell line lysates (35 ug/lane). The EFCAB4B antibody detected the EFCAB4B protein (arrow).

Anti-EFCAB4B Antibody (C-Terminus) IHC-plus™ - LS-B5351 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-EFCAB4B antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5351 concentration 5 ug/ml.

EFCAB4B Antibody - NBP1-55340 from Novus Biologicals

Prices	$139.00, $329.00
Sizes	20 µl, 100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: EFCAB4B Antibody [NBP1-55340] - Titration: 0.2-1 ug/ml, Positive Control: NCI-H226 cell lysate.

EFCAB4B Antibody - NBP1-76493 from Novus Biologicals

Prices	$329.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

EFCAB4B Antibody - NBP1-82687 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunocytochemistry/Immunofluorescence: EFCAB4B Antibody [NBP1-82687] Staining of human cell line A-431 shows positivity in nucleus, nucleoli, cytoplasm & golgi apparatus.

EFCAB4B Antibody - H00084766-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

EFCAB4B Antibody - H00084766-B01 from Novus Biologicals

Prices	$349.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot analysis of MGC4266 expression in transfected 293T cell line by MGC4266 MaxPab polyclonal antibody (B01). Lane 1: MGC4266 transfected lysate (45.60 KDa). Lane 2: Non-transfected lysate.

Anti-EFCAB4B antibody produced in rabbit - SAB2104876 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-EFCAB4B, antibody produced in rabbit: <B>Cat. No. SAB2104876</B>: Immunoblotting analysis of EFCAB4B in NCI-H226 cell lysate with EFCAB4B anitbody at 1 μg/mL.

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