CRACR2A

Gene Symbol	CRACR2A
Entrez Gene	84766
Alt Symbol	EFCAB4B
Species	Human
Gene Type	protein-coding
Description	calcium release activated channel regulator 2A
Other Description	CRAC channel regulator 2A|CRAC regulator 2A|Ca2+ release-activated Ca2+ (CRAC) channel regulator 2A|EF-hand calcium binding domain 4B|EF-hand calcium-binding domain-containing protein 4B|calcium release-activated calcium channel regulator 2A|calcium release-activated channel regulator 2A
Swissprots	Q9BSW2 B4E1X0 B9EK63
Accessions	EAW88858 EAW88859 EAW88860 Q9BSW2 AK057608 AK091124 AK304017 BAG64932 BC004524 AAH04524 BC150643 AAI50644 BU632650 BU634271 CR627161 DB214079 JF432156 ADZ15373 XM_006719021 XP_006719084 XM_011521034 XP_011519336 XM_011521035 XP_011519337 XM_011521036 XP_011519338 XM_011521037 XP_011519339 XM_011521038 XP_011519340 NM_001144959 NM_001144958 NP_001138430 NM_032680 NP_116069
Function	Ca(2+)-binding protein that plays a key role in store- operated Ca(2+) entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca(2+) concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca(2+) resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex. {ECO:0000269|PubMed:20418871}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:20418871}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EFCAB4B full length protein - ab164657 from Abcam Category Protein Source Wheat germ Species Human

CRACR2A / EFCAB4B Antibody Blocking Peptide - LS-E5456 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CRACR2A / EFCAB4B Antibody Blocking Peptide - LS-E31028 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CRACR2A / EFCAB4B Antibody Blocking Peptide - LS-E17512 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CRACR2A / EFCAB4B Antibody Blocking Peptide - LS-E17513 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human EFCAB4B Protein - H00084766-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

EFCAB4B Blocking Peptide - NBP1-76493PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

EFCAB4B-Antibody-N-term-Blocking-Peptide - BP17969a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EFCAB4B Peptide - GTX85142-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

EFCAB4B Blocking Peptide - 33R-4566 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EFCAB4B Blocking Peptide - 33R-1476 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EFCAB4B - H00084766-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EFCAB4B - H00084766-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EFCAB4B control peptide - AP26301CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

EFCAB4B Peptide - 6045P from ProSci Category Peptide Species Human

EFCAB4B fusion protein - Ag7358 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

EFCAB4B fusion protein - Ag7525 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human EFCAB4B, GST-tagged - EFCAB4B-12301H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human EF-hand calcium-binding domain-containing protein 4B(EFCAB4B) - CSB-YP863115HU CSB-EP863115HU CSB-BP863115HU CSB-MP863115HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EFCAB4B (transcript variant 3) - TP319097 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

EFCAB4B Recombinant Protein Antigen - NBP2-48692PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

EFCAB4B Recombinant Protein Antigen - NBP1-82687PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

EFCAB4B Peptide, Human - M34GP04740H from Creative Peptides Category Peptide Source Synthetic. Species Human

EF-hand calcium-binding domain-containing protein 4B (EFCAB4B), Recombinant Protein - MBS1289154 from MyBioSource Category Protein Prices $1,165.00, $1,165.00, $1,395.00, $1,395.00, $1,870.00, $1,870.00, $2,330.00, $2,330.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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