DKK3

Gene Symbol	DKK3
Entrez Gene	27122
Alt Symbol	REIC, RIG
Species	Human
Gene Type	protein-coding
Description	dickkopf WNT signaling pathway inhibitor 3
Other Description	RIG-like 5-6|RIG-like 7-1|dickkopf 3 homolog|dickkopf homolog 3|dickkopf-3|dickkopf-related protein 3|dkk-3|hDkk-3|regulated in glioma
Swissprots	Q9ULB7 A8K1I2 D3DQW1 Q9UBP4
Accessions	BAA87044 BAB84361 EAW68533 EAW68534 EAW68535 EAW68536 EAW68537 EAW68538 EAW68539 Q9UBP4 AB033421 BAA85488 AB034203 BAA90548 AB057591 BAB84360 AF052161 AF177396 AAF02676 AF400439 AAK92488 AK090952 BAC03555 AK092979 BAG52632 AK098756 AK225156 AK289897 BAF82586 AK295441 BAG58381 AK295539 BAG58448 AL535720 AY358378 AAQ88744 AY587550 AAS86757 BC007660 AAH07660 BQ690088 BQ690888 CB156451 DQ892906 ABM83832 DQ896157 ABM87156 H18461 U32331 AAC35996 XM_006718178 XP_006718241 NM_001018057 NP_001018067 NM_013253 NP_037385 NM_015881 NP_056965
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
Subcellular Location	Secreted.
Tissue Specificity	Highest expression in heart, brain, and spinal cord. {ECO:0000269|PubMed:10570958, ECO:0000269|Ref.4}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DKK3-Over-expression-Lysate - LY11441a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

DKK3 overexpression lysate - LY402468 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

DKK3 overexpression lysate - LY415712 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

DKK3 overexpression lysate - LY422711 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

DKK3 overexpression lysate - LY425422 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

DKK3 293 Cell Lysate - 407391 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Xenopus

DKK3 293 Cell Lysate - 402159 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Xenopus

Dkk-3 Overexpression Lysate (Native) - NBL1-09903 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Dkk-3 Overexpression Lysate (Native) - NBL1-09904 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Dkk-3 Overexpression Lysate (Native) - NBP2-08675 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Dkk-3 Overexpression Lysate (Native) - NBP2-09162 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

DKK3 Over-expression Lysate Product - GWB-FBEBBB from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

DKK3 Over-expression Lysate Product - GWB-845260 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Panoply™ Human DKK3 Knockdown Stable Cell Line - CSC-DC004329 from Creative biogene Category Cell Line Species Human

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