DKK3

Gene Symbol DKK3
Entrez Gene 27122
Alt Symbol REIC, RIG
Species Human
Gene Type protein-coding
Description dickkopf WNT signaling pathway inhibitor 3
Other Description RIG-like 5-6|RIG-like 7-1|dickkopf 3 homolog|dickkopf homolog 3|dickkopf-3|dickkopf-related protein 3|dkk-3|hDkk-3|regulated in glioma
Swissprots Q9ULB7 A8K1I2 D3DQW1 Q9UBP4
Accessions BAA87044 BAB84361 EAW68533 EAW68534 EAW68535 EAW68536 EAW68537 EAW68538 EAW68539 Q9UBP4 AB033421 BAA85488 AB034203 BAA90548 AB057591 BAB84360 AF052161 AF177396 AAF02676 AF400439 AAK92488 AK090952 BAC03555 AK092979 BAG52632 AK098756 AK225156 AK289897 BAF82586 AK295441 BAG58381 AK295539 BAG58448 AL535720 AY358378 AAQ88744 AY587550 AAS86757 BC007660 AAH07660 BQ690088 BQ690888 CB156451 DQ892906 ABM83832 DQ896157 ABM87156 H18461 U32331 AAC35996 XM_006718178 XP_006718241 NM_001018057 NP_001018067 NM_013253 NP_037385 NM_015881 NP_056965
Function Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
Subcellular Location Secreted.
Tissue Specificity Highest expression in heart, brain, and spinal cord. {ECO:0000269|PubMed:10570958, ECO:0000269|Ref.4}.

Dkk-3 (C-19) - sc-14959 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Dkk-3 (C-19): sc-14959. Western blot analysis of Dkk-3 expression in rat heart extract (A), SK-N-SH (B), H4 (C) and BC<sub>3</sub>H1 (D) whole cell lysates. Note in lanes B-D, Dkk-3 expression is downregulated in immortalized cell lines.

Dkk-3 (H-130) - sc-25518 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Dkk-3 (H-130): sc-25518. Western blot analysis of Dkk-3 expression in H4 (A) and A549 (B) whole cell lysates.

Dkk-3 (N-17) - sc-14956 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Dkk3 antibody - ab2459 from Abcam

Prices $390.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Ab2459 staining (2µg/ml) of 293 lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 12 hours. Detected by western blot using chemiluminescence.

Anti-Dkk3 antibody - ab187532 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human thyroid cancer tissue labelling Dkk3 with ab187532 at 1/100. Magnification: 200x.

Anti-Dkk3 antibody - ab115869 from Abcam

Prices $378.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab115869, at 5 µg/ml, staining Dkk3 in Formalin-fixed, Paraffin-embedded Human brain cortex by Immunohistochemistry.

Anti-Dkk3 antibody - ab136101 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Dkk3 antibody (ab136101) at 1/500 dilution + HepG2 cell lysate at 30 µg

Anti-Dkk3 antibody - ab166972 from Abcam

Prices $370.00
Sizes 250 µg
Host Rabbit
Clonality Polyclonal

Anti-Dkk3 antibody [4G7] - ab93923 from Abcam

Host Mouse
Clonality Monoclonal
Clone 4G7
All lanes : Anti-Dkk3 antibody [4G7] (ab93923) at 1/1000 dilutionLane 1 : HEK293 cell lysateLane 2 : MCF7 cell lysateLane 3 : HL7702 cell lysate

Anti-Dkk3 antibody [EPR15611] - ab186409 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15611
Anti-Dkk3 antibody [EPR15611] (ab186409) at 1/10000 dilution + Human fetal brain lysate at 20 µgSecondaryGoat anti-rabbit IgG, (H+L), peroxidase conjugate at 1/1000 dilution

Anti-Dkk3 antibody [EPR15611] (Alexa Fluor® 488) - ab201262 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15611
ab201262 staining Dkk3 in HepG2 cells. The cells were fixed with 100% methanol (5 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1%PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab201262 at a 1/100 dilution (shown in green) and ab195889, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 594), at a 1/250 dilution (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-DKK3 Antibody - LS-C332139 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human breast cancer using DKK3 antibody at dilution of 1:100 (200x lens).

Anti-DKK3 Antibody - LS-C125460 from LifeSpan Bioscience

Prices $575.00
Sizes 500 µg
Host Mouse
Clonality Monoclonal

Anti-DKK3 Antibody - LS-C125461 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DKK3 Antibody (C-Terminus, APC) - LS-C244151 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK3 Antibody (C-Terminus, Biotin) - LS-C244152 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK3 Antibody (C-Terminus, AP) - LS-C244153 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK3 Antibody (C-Terminus, FITC) - LS-C244154 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK3 Antibody (N-Terminus, AP) - LS-C244155 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK3 Antibody (N-Terminus, APC) - LS-C244156 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK3 Antibody (aa51-100) - LS-C146493 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DKK3 antibody LS-C146493 Western blot of 293T Cell lysate. Antibody concentration 1 ug/ml.

Anti-DKK3 Antibody - LS-C147018 from LifeSpan Bioscience

Prices $410.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of DKK3 antibody LS-C147018.

Anti-DKK3 Antibody (C-Terminus, PE) - LS-C244157 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK3 Antibody (N-Terminus, FITC) - LS-C244158 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DKK3 Antibody (clone 4G7) - LS-C108794 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4G7
Western blot using DKK3 mouse monoclonal antibody against HEK293 (1), MCF-7 (2) and HL7702 (3) cell lysate.
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