DKK3

Gene Symbol	DKK3
Entrez Gene	27122
Alt Symbol	REIC, RIG
Species	Human
Gene Type	protein-coding
Description	dickkopf WNT signaling pathway inhibitor 3
Other Description	RIG-like 5-6|RIG-like 7-1|dickkopf 3 homolog|dickkopf homolog 3|dickkopf-3|dickkopf-related protein 3|dkk-3|hDkk-3|regulated in glioma
Swissprots	Q9ULB7 A8K1I2 D3DQW1 Q9UBP4
Accessions	BAA87044 BAB84361 EAW68533 EAW68534 EAW68535 EAW68536 EAW68537 EAW68538 EAW68539 Q9UBP4 AB033421 BAA85488 AB034203 BAA90548 AB057591 BAB84360 AF052161 AF177396 AAF02676 AF400439 AAK92488 AK090952 BAC03555 AK092979 BAG52632 AK098756 AK225156 AK289897 BAF82586 AK295441 BAG58381 AK295539 BAG58448 AL535720 AY358378 AAQ88744 AY587550 AAS86757 BC007660 AAH07660 BQ690088 BQ690888 CB156451 DQ892906 ABM83832 DQ896157 ABM87156 H18461 U32331 AAC35996 XM_006718178 XP_006718241 NM_001018057 NP_001018067 NM_013253 NP_037385 NM_015881 NP_056965
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
Subcellular Location	Secreted.
Tissue Specificity	Highest expression in heart, brain, and spinal cord. {ECO:0000269|PubMed:10570958, ECO:0000269|Ref.4}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Dkk3 full length protein - ab155717 from Abcam Category Protein Prices $352.00 Sizes 200 µg Source HEK 293 cells Species Human

Active human Dkk3 full length protein - ab186078 from Abcam Category Protein Prices $110.00, $308.00 Sizes 2 µg, 10 µg Source CHO Species Human

Human Dkk3 full length protein - ab131852 from Abcam Category Protein Source Wheat germ Species Human

Human Dkk3 full length protein - ab151874 from Abcam Category Protein Source HEK 293 cells Species Human

Human Dkk3 full length protein - ab131700 from Abcam Category Protein Source E. coli Species Human

DKK3 Antibody Blocking Peptide - LS-E3796 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DKK3 Antibody Blocking Peptide - LS-E25318 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DKK3 Antibody Blocking Peptide - LS-E23230 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Dkk-3 Recombinant Protein - H00027122-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Dkk-3 Protein - NBP2-23001 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Species Human

Dkk-3 Peptide - P0531 from Novus Biologicals Category Peptide Species Human

DKK3-Antibody-N-term-Blocking-Peptide - BP1523a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DKK3 blocking peptide - GTX89935-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

DKK3 blocking peptide - GTX89800-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human Dkk-3, CF - 1118-DK-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ala22-Ile350, with a C-terminal 10-His tag

Human DKK3 protein - orb168236 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

Human Dkk3 protein - orb49352 from Biorbyt Category Protein Prices $272.00, $366.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source HEK293

DIRAS1 protein (His tag) - 80R-1486 from Fitzgerald Category Protein Prices $255.00 Sizes 50 µg Source E.coli

DKK3 Blocking Peptide - 33R-10565 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

DKK3 protein (His tag) - 80R-2410 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

DKK3 Peptide - AC21-0146-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

DKK3 Peptide - AC21-0369-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Dickkopf-3 (DKK3) - AR31139PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 10 µg Source CHO cells Species Human

Dickkopf-3 (DKK3) - AR31139PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 2 µg Source CHO cells Species Human

Dickkopf-3 (DKK3) (22-350, His-tag) - AR50490PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

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