DKK3
| Gene Symbol | DKK3 |
|---|---|
| Entrez Gene | 27122 |
| Alt Symbol | REIC, RIG |
| Species | Human |
| Gene Type | protein-coding |
| Description | dickkopf WNT signaling pathway inhibitor 3 |
| Other Description | RIG-like 5-6|RIG-like 7-1|dickkopf 3 homolog|dickkopf homolog 3|dickkopf-3|dickkopf-related protein 3|dkk-3|hDkk-3|regulated in glioma |
| Swissprots | Q9ULB7 A8K1I2 D3DQW1 Q9UBP4 |
| Accessions | BAA87044 BAB84361 EAW68533 EAW68534 EAW68535 EAW68536 EAW68537 EAW68538 EAW68539 Q9UBP4 AB033421 BAA85488 AB034203 BAA90548 AB057591 BAB84360 AF052161 AF177396 AAF02676 AF400439 AAK92488 AK090952 BAC03555 AK092979 BAG52632 AK098756 AK225156 AK289897 BAF82586 AK295441 BAG58381 AK295539 BAG58448 AL535720 AY358378 AAQ88744 AY587550 AAS86757 BC007660 AAH07660 BQ690088 BQ690888 CB156451 DQ892906 ABM83832 DQ896157 ABM87156 H18461 U32331 AAC35996 XM_006718178 XP_006718241 NM_001018057 NP_001018067 NM_013253 NP_037385 NM_015881 NP_056965 |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Highest expression in heart, brain, and spinal cord. {ECO:0000269|PubMed:10570958, ECO:0000269|Ref.4}. |
Dkk-3 CRISPR/Cas9 KO Plasmid (h) - sc-402970 from Santa Cruz Biotechnology
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Dkk-3 HDR Plasmid (h) - sc-402970-HDR from Santa Cruz Biotechnology
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Dkk-3 Double Nickase Plasmid (h) - sc-402970-NIC from Santa Cruz Biotechnology
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Dkk-3 Double Nickase Plasmid (h2) - sc-402970-NIC-2 from Santa Cruz Biotechnology
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Dkk-3 CRISPR Activation Plasmid (h) - sc-402970-ACT from Santa Cruz Biotechnology
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Dkk-3 CRISPR Activation Plasmid (h2) - sc-402970-ACT-2 from Santa Cruz Biotechnology
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Dkk-3 Lentiviral Activation Particles (h) - sc-402970-LAC from Santa Cruz Biotechnology
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Dkk-3 Lentiviral Activation Particles (h2) - sc-402970-LAC-2 from Santa Cruz Biotechnology
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Dkk-3 siRNA (h) - sc-41102 from Santa Cruz Biotechnology
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Dkk-3 shRNA Plasmid (h) - sc-41102-SH from Santa Cruz Biotechnology
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Dkk-3 shRNA (h) Lentiviral Particles - sc-41102-V from Santa Cruz Biotechnology
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Dkk-3 RNAi - H00027122-R01 from Novus Biologicals
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Dkk-3 RNAi - H00027122-R03 from Novus Biologicals
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MISSION® esiRNA - EHU072211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7276 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7276 from Sigma-Aldrich
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DKK3 siRNA (Human) - CRH8976 from Cohesion Biosciences
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Dkk-3 RNAi - H00027122-R02 from Novus Biologicals
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DKK3 - MBS8210407 from MyBioSource
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shRNA set against Human DKK3 (NM_015881.5) - SHH278365 from Creative biogene
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shRNA set against Human DKK3(NM_001018057.1) - SHH006185 from Creative biogene
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Human DKK3 siRNA - orb269478 from Biorbyt
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DKK3 shRNA Plasmid (Human) - CHH8976 from Cohesion Biosciences
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DKK3 miRNA 3'UTR clone - MiUTR1H-02859 from Creative biogene
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DKK3 miRNA 3'UTR clone - MiUTR3H-07651 from Creative biogene
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