| Gene Symbol |
DEFA5
|
| Entrez Gene |
1670
|
| Alt Symbol |
DEF5, HD-5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
defensin, alpha 5, Paneth cell-specific
|
| Other Description |
HD5(20-94)|defensin 5|defensin, alpha 5, preproprotein|defensin-5
|
| Swissprots |
Q3KNV2 A0JDY6 Q01523
|
| Accessions |
AAA35754 AAT68886 EAW80489 Q01523 BC069690 AAH69690 BC107079 AAI07080 BM854660 BP419449 HQ448430 ADQ32910 NM_021010 NP_066290
|
| Function |
Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:17088326}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:12021776}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:12021776}. Note=Peptides HD5(20-94), HD5(23- 94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form.
|
| Tissue Specificity |
Paneth cells of the small intestine (at protein level). {ECO:0000269|PubMed:12021776}.
|