DEFA5

Gene Symbol DEFA5
Entrez Gene 1670
Alt Symbol DEF5, HD-5
Species Human
Gene Type protein-coding
Description defensin, alpha 5, Paneth cell-specific
Other Description HD5(20-94)|defensin 5|defensin, alpha 5, preproprotein|defensin-5
Swissprots Q3KNV2 A0JDY6 Q01523
Accessions AAA35754 AAT68886 EAW80489 Q01523 BC069690 AAH69690 BC107079 AAI07080 BM854660 BP419449 HQ448430 ADQ32910 NM_021010 NP_066290
Function Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:17088326}.
Subcellular Location Secreted {ECO:0000269|PubMed:12021776}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:12021776}. Note=Peptides HD5(20-94), HD5(23- 94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form.
Tissue Specificity Paneth cells of the small intestine (at protein level). {ECO:0000269|PubMed:12021776}.

α-defensin 5 (8c8) - sc-53997 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

α-defensin 5 (L-13) - sc-25877 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
α-defensin 5 (L-13): sc-25877. Western blot analysis of α-defensin 5 expression in non-transfected 293T: sc-117752 (A) and human α-defensin 5 transfected 293T: sc-371609 (B) whole cell lysates.

α-defensin 5 (H-69) - sc-368466 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-alpha 5 Defensin antibody - ab167591 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-alpha 5 Defensin antibody (ab167591) at 1 µg/mlLane 1 : alpha 5 Defensin transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-rabbit HRP at 1/2500 dilution

Anti-alpha 5 Defensin antibody [8C8] - ab90802 from Abcam

Prices $379.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 8C8
ab90802 at 1/50 dilution staining alpha 5 Defensin in human Ileus tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin embedded tissue sections).

Anti-alpha 5 Defensin antibody [EPR14309(B)] - ab180515 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14309(B)
Anti-alpha 5 Defensin antibody [EPR14309(B)] (ab180515) at 1/10000 dilution + Human small intestine lysate at 20 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab136636) at 1/500 dilution

Anti-alpha Defensin NP5 antibody [8C8] - ab62757 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8C8
IHC image of Defensin NP5 staining in human duodenum formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab62757, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-alpha Defensin NP5 antibody [8C8] - BSA and Azide free - ab175348 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8C8

Anti-DEFA5 / Defensin 5 Antibody (C-Terminus) - LS-C37785 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-DEFA5 / Defensin 5 Antibody (C-Terminus) - LS-C37786 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-DEFA5 / Defensin 5 Antibody (C-Terminus, HRP) - LS-C37787 from LifeSpan Bioscience

Prices $485.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-DEFA5 / Defensin 5 Antibody (C-Terminus, FITC) - LS-C37788 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-DEFA5 / Defensin 5 Antibody - LS-C50934 from LifeSpan Bioscience

Prices $785.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DEFA5 / Defensin 5 Antibody - LS-C121267 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-DEFA5 / Defensin 5 Antibody (aa20-94) - LS-C124300 from LifeSpan Bioscience

Prices $740.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DEFA5 / Defensin 5 Antibody (clone R3) - LS-C131098 from LifeSpan Bioscience

Prices $665.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone R3

Anti-DEFA5 / Defensin 5 Antibody (clone 8C8) - LS-C140136 from LifeSpan Bioscience

Prices $665.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 8C8

Anti-DEFA5 / Defensin 5 Antibody (clone 8C8, Biotin) - LS-C141649 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8C8

Anti-DEFA5 / Defensin 5 Antibody (clone R3) - LS-C140190 from LifeSpan Bioscience

Prices $665.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone R3

Anti-DEFA5 / Defensin 5 Antibody (clone 8C8, DY650) - LS-C141650 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8C8

Anti-DEFA5 / Defensin 5 Antibody (clone 8C8, DY488) - LS-C141651 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8C8

Anti-DEFA5 / Defensin 5 Antibody (clone R3) - LS-C202059 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone R3

Anti-DEFA5 / Defensin 5 Antibody (clone 8C8, DY550) - LS-C141653 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8C8

Anti-DEFA5 / Defensin 5 Antibody (clone 8C8, HRP) - LS-C141652 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8C8

Anti-DEFA5 / Defensin 5 Antibody (aa20-94, FITC) - LS-C302593 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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