DEFA5

Gene Symbol DEFA5
Entrez Gene 1670
Alt Symbol DEF5, HD-5
Species Human
Gene Type protein-coding
Description defensin, alpha 5, Paneth cell-specific
Other Description HD5(20-94)|defensin 5|defensin, alpha 5, preproprotein|defensin-5
Swissprots Q3KNV2 A0JDY6 Q01523
Accessions AAA35754 AAT68886 EAW80489 Q01523 BC069690 AAH69690 BC107079 AAI07080 BM854660 BP419449 HQ448430 ADQ32910 NM_021010 NP_066290
Function Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing. {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:17088326}.
Subcellular Location Secreted {ECO:0000269|PubMed:12021776}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:12021776}. Note=Peptides HD5(20-94), HD5(23- 94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form.
Tissue Specificity Paneth cells of the small intestine (at protein level). {ECO:0000269|PubMed:12021776}.

α-defensin 5 CRISPR/Cas9 KO Plasmid (h) - sc-404991 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-defensin 5 HDR Plasmid (h) - sc-404991-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-defensin 5 Double Nickase Plasmid (h) - sc-404991-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-defensin 5 Double Nickase Plasmid (h2) - sc-404991-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-defensin 5 CRISPR Activation Plasmid (h) - sc-404991-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-defensin 5 CRISPR Activation Plasmid (h2) - sc-404991-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-defensin 5 Lentiviral Activation Particles (h) - sc-404991-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-defensin 5 Lentiviral Activation Particles (h2) - sc-404991-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

α-defensin 5 siRNA (h) - sc-72025 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

α-defensin 5 shRNA Plasmid (h) - sc-72025-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

α-defensin 5 shRNA (h) Lentiviral Particles - sc-72025-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU057841 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7088 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7088 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00903 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00903

DEFA5 siRNA (Human) - CRH1179 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DEFA5 - MBS8208905 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DEFA5 (NM_021010.1) - SHH276409 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human DEFA5(NM_021010.1) - SHG228203 from Creative biogene

Category siRNA
Species Reactivities Human

DEFA5 shRNA Plasmid (Human) - CHH1179 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DEFA5 miRNA 3'UTR clone - MiUTR1H-02753 from Creative biogene

Species Reactivities Human
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