| Gene Symbol | Sirt3 |
|---|---|
| Entrez Gene | 64384 |
| Alt Symbol | 2310003L23Rik, AI848213, Sir2l3 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | sirtuin 3 |
| Other Description | NAD-dependent deacetylase sirtuin-3|NAD-dependent protein deacetylase sirtuin-3|SIR2-like protein 3|SIRT3L mitochondrial|mSIR2L3|mitochondrial protein lysine deacetylase|regulatory protein SIR2 homolog 3|silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3 |
| Swissprots | C6ZII7 Q9EPA8 Q8R104 B9W0A9 |
| Accessions | AAG33227 EDL17961 EDL17962 EDL17963 Q8R104 AF299338 AAG39257 AF299339 AAG39258 AK075861 BAC36012 AK086910 AK165407 BC025878 AAH25878 BF681854 CB953804 CT010402 CAJ18608 EU886466 ACJ70655 FJ621493 ACM68947 XM_006536222 XP_006536285 XM_006536223 XP_006536286 NM_001127351 NP_001120823 NM_001177804 NP_001171275 NM_022433 NP_071878 |
| Function | NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. {ECO:0000269|PubMed:16790548, ECO:0000269|PubMed:17923681, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:21172655, ECO:0000269|PubMed:21858060, ECO:0000269|PubMed:23835326, ECO:0000269|PubMed:24252090}. |
| Subcellular Location | Isoform L: Mitochondrion matrix. |
| Tissue Specificity | Strongly expressed in liver and kidney. Weakly expressed in lung. {ECO:0000269|PubMed:11056054}. |
| Top Pathways | Central carbon metabolism in cancer |