Sirt3

Gene Symbol Sirt3
Entrez Gene 64384
Alt Symbol 2310003L23Rik, AI848213, Sir2l3
Species Mouse
Gene Type protein-coding
Description sirtuin 3
Other Description NAD-dependent deacetylase sirtuin-3|NAD-dependent protein deacetylase sirtuin-3|SIR2-like protein 3|SIRT3L mitochondrial|mSIR2L3|mitochondrial protein lysine deacetylase|regulatory protein SIR2 homolog 3|silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3
Swissprots C6ZII7 Q9EPA8 Q8R104 B9W0A9
Accessions AAG33227 EDL17961 EDL17962 EDL17963 Q8R104 AF299338 AAG39257 AF299339 AAG39258 AK075861 BAC36012 AK086910 AK165407 BC025878 AAH25878 BF681854 CB953804 CT010402 CAJ18608 EU886466 ACJ70655 FJ621493 ACM68947 XM_006536222 XP_006536285 XM_006536223 XP_006536286 NM_001127351 NP_001120823 NM_001177804 NP_001171275 NM_022433 NP_071878
Function NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. {ECO:0000269|PubMed:16790548, ECO:0000269|PubMed:17923681, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:21172655, ECO:0000269|PubMed:21858060, ECO:0000269|PubMed:23835326, ECO:0000269|PubMed:24252090}.
Subcellular Location Isoform L: Mitochondrion matrix.
Tissue Specificity Strongly expressed in liver and kidney. Weakly expressed in lung. {ECO:0000269|PubMed:11056054}.
Top Pathways Central carbon metabolism in cancer

SIRT3 CRISPR/Cas9 KO Plasmid (m) - sc-425704 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIRT3 HDR Plasmid (m) - sc-425704-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIRT3 Double Nickase Plasmid (m) - sc-425704-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIRT3 Double Nickase Plasmid (m2) - sc-425704-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIRT3 CRISPR Activation Plasmid (m) - sc-425704-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIRT3 CRISPR Activation Plasmid (m2) - sc-425704-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIRT3 Lentiviral Activation Particles (m) - sc-425704-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIRT3 Lentiviral Activation Particles (m2) - sc-425704-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

SIRT3 siRNA (m) - sc-61556 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

SIRT3 shRNA Plasmid (m) - sc-61556-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

SIRT3 shRNA (m) Lentiviral Particles - sc-61556-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CompoZr® Knockout ZFN Kit - CKOZFN41198 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND41198 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SIRT3 siRNA (Mouse) - CRM6309 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

SIRT3 - MBS8208505 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse SIRT3 (NM_022433.2) - SHH407756 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse SIRT3 siRNA - orb285785 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

SIRT3 shRNA Plasmid (Mouse) - CHM6309 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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