Sirt3

Gene Symbol	Sirt3
Entrez Gene	64384
Alt Symbol	2310003L23Rik, AI848213, Sir2l3
Species	Mouse
Gene Type	protein-coding
Description	sirtuin 3
Other Description	NAD-dependent deacetylase sirtuin-3|NAD-dependent protein deacetylase sirtuin-3|SIR2-like protein 3|SIRT3L mitochondrial|mSIR2L3|mitochondrial protein lysine deacetylase|regulatory protein SIR2 homolog 3|silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3
Swissprots	C6ZII7 Q9EPA8 Q8R104 B9W0A9
Accessions	AAG33227 EDL17961 EDL17962 EDL17963 Q8R104 AF299338 AAG39257 AF299339 AAG39258 AK075861 BAC36012 AK086910 AK165407 BC025878 AAH25878 BF681854 CB953804 CT010402 CAJ18608 EU886466 ACJ70655 FJ621493 ACM68947 XM_006536222 XP_006536285 XM_006536223 XP_006536286 NM_001127351 NP_001120823 NM_001177804 NP_001171275 NM_022433 NP_071878
Function	NAD-dependent protein deacetylase. Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues. Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP synthase subunit ATP5O. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels. {ECO:0000269|PubMed:16790548, ECO:0000269|PubMed:17923681, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:21172655, ECO:0000269|PubMed:21858060, ECO:0000269|PubMed:23835326, ECO:0000269|PubMed:24252090}.
Subcellular Location	Isoform L: Mitochondrion matrix.
Tissue Specificity	Strongly expressed in liver and kidney. Weakly expressed in lung. {ECO:0000269|PubMed:11056054}.
Top Pathways	Central carbon metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

M-Sirt3-Antibody-C-term-Blocking-peptide - BP6242b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Sirt3 Peptide - 42-388P from ProSci Category Peptide Species Mouse

Recombinant Sirtuin 3 (SIRT3) - RPE913Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Sirtuin 3 (SIRT3) - RPE913Mu02 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse NAD-dependent protein deacetylase sirtuin-3(Sirt3) - CSB-YP848095MO CSB-EP848095MO CSB-BP848095MO CSB-MP848095MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Sirtuin 3 Protein (Recombinant) - abx167224 from Abbexa Category Protein Source Mouse Species Mouse

Sirtuin 3, Peptide - MBS427701 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Pig

Recombinant Sirtuin 3 (SIRT3) - RPU51870 from Biomatik Category Protein Prices $180.00, $369.00, $564.00, $672.40 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

SIRT3 Recombinant Protein (OPCD07003) - OPCD07003 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

NAD-dependent protein deacetylase sirtuin-3 (Sirt3), Recombinant Protein - MBS1486352 from MyBioSource Category Protein Prices $1,010.00, $1,010.00, $1,235.00, $1,235.00, $1,550.00, $1,550.00, $2,015.00, $2,015.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

Sirtuin 3 (SIRT3), Recombinant Protein - MBS2025218 from MyBioSource Category Protein Prices $175.00, $370.00, $575.00 Sizes 10 µg, 50 µg, 100 µg Source E Coli

Active Sirtuin 3 (SIRT3) - RPU54972 from Biomatik Category Protein Prices $664.00, $827.00, $3,100.00 Sizes 50 µg, 100 µg, 1 mg Source E. coli Species Mouse

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