UBE2W

Gene Symbol UBE2W
Entrez Gene 55284
Alt Symbol UBC-16, UBC16
Species Human
Gene Type protein-coding
Description ubiquitin-conjugating enzyme E2W (putative)
Other Description N-terminus-conjugating E2|ubiquitin carrier protein W|ubiquitin-conjugating enzyme 16|ubiquitin-conjugating enzyme 2W|ubiquitin-conjugating enzyme E2 W|ubiquitin-protein ligase W
Swissprots B4DIV1 Q1XBE0 Q9NV07 Q9HAG6 Q96B02 Q9H823
Accessions EAW87009 EAW87010 EAW87011 EAW87012 Q96B02 AK001873 BAA91954 AK021735 BAB13883 AK024050 BAB14800 AK123531 AK225554 AK295792 BAG58613 AY948289 AAY24555 BC010900 AAH10900 BC016326 AAH16326 BU155172 BX538145 BX648427 CR457275 CAG33556 DA352184 EU446497 ABZ92026 NM_001001481 NP_001001481 NM_001271015 NP_001257944 NM_018299 NP_060769 NR_073119 NR_073120 NR_073121 NM_001001482
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2. {ECO:0000269|PubMed:19111657, ECO:0
Subcellular Location Nucleus {ECO:0000269|PubMed:16368532}. Note=In the nucleus, colocalizes with FANCL.
Tissue Specificity Widely expressed, with highest expression in brain, liver, pancreas and heart. {ECO:0000269|PubMed:16368532}.
Top Pathways Ubiquitin mediated proteolysis

UBE2W (D-20) - sc-87491 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

UBE2W (H-48) - sc-382657 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

UBE2W (C-15) - sc-87490 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-UBE2W antibody - ab55034 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab55034 UBE2W antibody at 1ug/ml.

Anti-UBE2W antibody - ab116127 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-UBE2W antibody (ab116127) at 1/100 dilution + MCF7 cell line lysates at 35 µg

Anti-UBE2W Antibody (aa105-133, AP) - LS-C242376 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE2W Antibody (aa105-133, APC) - LS-C242377 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE2W Antibody (aa105-133, FITC) - LS-C242378 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE2W Antibody (aa105-133, Biotin) - LS-C242380 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE2W Antibody (aa105-133, PE) - LS-C242381 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE2W Antibody (aa105-133, Azide-free, HRP) - LS-C247179 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE2W Antibody (aa104-133) - LS-C326145 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBE2W Antibody (aa105-133) - LS-C160388 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
UBE2W Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human liver tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

UBE2W Antibody - NBP1-92558 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: UBE2W Antibody [NBP1-92558] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

UBE2W Antibody (7G4) - H00055284-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 7G4

UBE2W Antibody - H00055284-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

UBE2W Polyclonal Antibody - bs-8385R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Paraformaldehyde-fixed, paraffin embedded rat brain; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with UBE2W Polyclonal Antibody, Unconjugated (bs-8385R ) at 1:200 overnight at 4°C, followed by a conjugated secondary and DAB staining.

ANTI-UBE2W (C-TERM) antibody produced in rabbit - SAB1304545 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>UBE2W (C-term): <B>Cat. No. SAB1304545</B>: UBE2W in Human liver tissue with UBE2W antibody (C-term) at 10 μg/mL.

UBE2W-Antibody-C-term - AP13607b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
UBE2W Antibody (C-term) (Cat. #AP13607b) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the UBE2W antibody detected the UBE2W protein (arrow).

UBE2W Antibody - C-terminal region (OAAB09908) - OAAB09908 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

UBE2W antibody - 70R-21118 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Ubiquitin-conjugating enzyme E2 W antibody - orb243349 from Biorbyt

Prices $400.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

UBE2W Antibody - abx027497 from Abbexa

Host Rabbit
Clonality Polyclonal

Ubiquitin-conjugating enzyme E2 W Antibody - abx109392 from Abbexa

Host Rabbit
Clonality Polyclonal

Ubiquitin-conjugating enzyme E2 W Antibody (Biotin) - abx106052 from Abbexa

Host Rabbit
Clonality Polyclonal
Search more