| Gene Symbol |
UBE2W
|
| Entrez Gene |
55284
|
| Alt Symbol |
UBC-16, UBC16
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2W (putative)
|
| Other Description |
N-terminus-conjugating E2|ubiquitin carrier protein W|ubiquitin-conjugating enzyme 16|ubiquitin-conjugating enzyme 2W|ubiquitin-conjugating enzyme E2 W|ubiquitin-protein ligase W
|
| Swissprots |
B4DIV1 Q1XBE0 Q9NV07 Q9HAG6 Q96B02 Q9H823
|
| Accessions |
EAW87009 EAW87010 EAW87011 EAW87012 Q96B02 AK001873 BAA91954 AK021735 BAB13883 AK024050 BAB14800 AK123531 AK225554 AK295792 BAG58613 AY948289 AAY24555 BC010900 AAH10900 BC016326 AAH16326 BU155172 BX538145 BX648427 CR457275 CAG33556 DA352184 EU446497 ABZ92026 NM_001001481 NP_001001481 NM_001271015 NP_001257944 NM_018299 NP_060769 NR_073119 NR_073120 NR_073121 NM_001001482
|
| Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2. {ECO:0000269|PubMed:19111657, ECO:0
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16368532}. Note=In the nucleus, colocalizes with FANCL.
|
| Tissue Specificity |
Widely expressed, with highest expression in brain, liver, pancreas and heart. {ECO:0000269|PubMed:16368532}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|