UBE2W

Gene Symbol	UBE2W
Entrez Gene	55284
Alt Symbol	UBC-16, UBC16
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2W (putative)
Other Description	N-terminus-conjugating E2|ubiquitin carrier protein W|ubiquitin-conjugating enzyme 16|ubiquitin-conjugating enzyme 2W|ubiquitin-conjugating enzyme E2 W|ubiquitin-protein ligase W
Swissprots	B4DIV1 Q1XBE0 Q9NV07 Q9HAG6 Q96B02 Q9H823
Accessions	EAW87009 EAW87010 EAW87011 EAW87012 Q96B02 AK001873 BAA91954 AK021735 BAB13883 AK024050 BAB14800 AK123531 AK225554 AK295792 BAG58613 AY948289 AAY24555 BC010900 AAH10900 BC016326 AAH16326 BU155172 BX538145 BX648427 CR457275 CAG33556 DA352184 EU446497 ABZ92026 NM_001001481 NP_001001481 NM_001271015 NP_001257944 NM_018299 NP_060769 NR_073119 NR_073120 NR_073121 NM_001001482
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2. {ECO:0000269|PubMed:19111657, ECO:0
Subcellular Location	Nucleus {ECO:0000269|PubMed:16368532}. Note=In the nucleus, colocalizes with FANCL.
Tissue Specificity	Widely expressed, with highest expression in brain, liver, pancreas and heart. {ECO:0000269|PubMed:16368532}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

UBE2W-Over-expression-Lysate - LY13562a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

UBE2W 293T Cell Transient Overexpression Lysate(Denatured) - H00055284-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

UBE2W 293 Cell Lysate - 402321 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

UBE2W Overexpression Lysate (Denatured) - H00055284-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

UBE2W Overexpression Lysate (Native) - NBP2-09080 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

UBE2W Overexpression Lysate (Native) - NBP2-08982 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

UBE2W Overexpression Lysate (Native) - NBL1-17549 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

UBE2W Over-expression Lysate Product - GWB-57C271 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human UBE2W Knockdown Stable Cell Line - CSC-DC016979 from Creative biogene Category Cell Line Species Human

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