UBE2W

Gene Symbol	UBE2W
Entrez Gene	55284
Alt Symbol	UBC-16, UBC16
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2W (putative)
Other Description	N-terminus-conjugating E2|ubiquitin carrier protein W|ubiquitin-conjugating enzyme 16|ubiquitin-conjugating enzyme 2W|ubiquitin-conjugating enzyme E2 W|ubiquitin-protein ligase W
Swissprots	B4DIV1 Q1XBE0 Q9NV07 Q9HAG6 Q96B02 Q9H823
Accessions	EAW87009 EAW87010 EAW87011 EAW87012 Q96B02 AK001873 BAA91954 AK021735 BAB13883 AK024050 BAB14800 AK123531 AK225554 AK295792 BAG58613 AY948289 AAY24555 BC010900 AAH10900 BC016326 AAH16326 BU155172 BX538145 BX648427 CR457275 CAG33556 DA352184 EU446497 ABZ92026 NM_001001481 NP_001001481 NM_001271015 NP_001257944 NM_018299 NP_060769 NR_073119 NR_073120 NR_073121 NM_001001482
Function	Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2. {ECO:0000269|PubMed:19111657, ECO:0
Subcellular Location	Nucleus {ECO:0000269|PubMed:16368532}. Note=In the nucleus, colocalizes with FANCL.
Tissue Specificity	Widely expressed, with highest expression in brain, liver, pancreas and heart. {ECO:0000269|PubMed:16368532}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human UBE2W full length protein - ab188717 from Abcam Category Protein Prices $276.00 Sizes 50 µg Source E. coli Species Human

Active human UBE2W full length protein - ab188728 from Abcam Category Protein Prices $265.00 Sizes 50 µg Source E. coli Species Human

Human UBE2W full length protein - ab167921 from Abcam Category Protein Source E. coli Species Human

Human UBE2W full length protein - ab124868 from Abcam Category Protein Source E. coli Species Human

UBE2W Antibody Blocking Peptide - LS-E2562 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2W Partial Recombinant Protein - H00055284-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

UBE2W Recombinant Protein - H00055284-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 10 ug 25 ug Species Human

Recombinant Human UBE2W Protein - NBP1-72325 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

UBE2W-Antibody-C-term-Blocking-peptide - BP13607b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human His6-UBE2W Isoform 1, CF - E2-740-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal 6-His tag

Recombinant Human His6-UBE2W Isoform 1, CF - E2-740-100 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal 6-His tag

Recombinant Human His6-UBE2W Isoform 2, CF - E2-725-050 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal 6-His tag

Recombinant Human His6-UBE2W Isoform 2, CF - E2-725-100 from R&D Systems Category Protein Source E. coli-derived, Contains an N-terminal 6-His tag

UBE2W Protein (OPPA00013) - OPPA00013 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Escherichia Coli.

Human UBE2W protein (His Tag) - orb139845 from Biorbyt Category Protein Prices $196.00, $298.00 Sizes 50 μg, 100 μg Source E. coli Species Human

Human UBE2W protein - orb169513 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human UBE2W protein - orb244902 from Biorbyt Category Protein Prices $213.00, $408.00, $680.00, $1,122.00, $1,777.00 Sizes 10 μg, 50 μg, 200 μg, 500 μg, 1 mg Species Human

UBE2W protein (His tag) - 80R-1835 from Fitzgerald Category Protein Prices $295.00 Sizes 100 µg Source E.coli

UBE2W (1-151, His-tag) - AR39019PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

UBE2W (1-151, His-tag) - AR39019PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

UBE2W - H00055284-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

UBE2W - H00055284-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UBE2W - H00055284-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Ubiquitin Conjugating Enzyme E2W, Human Recombinant - 228-12269-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

UBE2W, 1-151aa, Human, His tag, E.coli - 01-2014-W from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

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