CHST15

Gene Symbol	CHST15
Entrez Gene	51363
Alt Symbol	BRAG, GALNAC4S-6ST
Species	Human
Gene Type	protein-coding
Description	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
Other Description	B cell RAG associated protein (GALNAC4S-6ST)|B-cell RAG-associated gene protein|carbohydrate sulfotransferase 15|hBRAG
Swissprots	Q86VM4 O60474 O60338 Q7LFX5
Accessions	BAA83686 EAW49273 EAW49274 EAW49275 EAW49276 Q7LFX5 AB011170 BAA25524 AB062423 BAB72145 AF026477 AAC71691 AK294961 BAG58035 AK299546 BAG61492 BC027908 AAH27908 BC050540 AAH50540 BC075813 AAH75813 BM193389 BM977716 CR749804 CAH18664 XM_005269891 XP_005269948 XM_005269892 XP_005269949 XM_005269893 XP_005269950 XM_005269894 XP_005269951 XM_006717891 XP_006717954 XM_011539857 XP_011538159 XR_945773 NM_001270764 NP_001257693 NM_001270765 NP_001257694 NM_014863 NP_055678 NM_015892 NP_056976
Function	Sulfotransferase that transfers sulfate from 3'- phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non- reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B- cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo. {ECO:0000269|PubMed:11572857, ECO:0000269|PubMed:12874280}.
Subcellular Location	Golgi apparatus membrane {ECO:0000305|PubMed:10749872}; Single-pass type II membrane protein {ECO:0000305|PubMed:10749872}. Note=A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.
Tissue Specificity	Expressed in B-cell-enriched tissues but not in fetal or adult thymus. Expressed in fetal and adult spleen, lymph node, tonsil, bone marrow and peripheral leukocytes. Not expressed in T-cells. In pro-B, pre-B, and mature B-cell lines, it colocalizes with RAG1. {ECO:0000269|PubMed:9754571}.
Top Pathways	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GalNAc4S-6ST (G-14) - sc-160349 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

GalNAc4S-6ST (E-17) - sc-160348 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

GalNAc4S-6ST (D-15) - sc-160347 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-ST4S6 antibody - ab80887 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ST4S6 antibody - C-terminal - ab176437 from Abcam Host Rabbit Clonality Polyclonal

Anti-CHST15 Antibody (aa99-561) - LS-C63449 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-CHST15 Antibody (aa362-411) - LS-C82503 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Carbohydrate Sulfotransferase 15/CHST15 Antibody - AF3365 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

Carbohydrate Sulfotransferase 15/CHST15 Antibody (388421) - MAB3365 from Novus Biologicals Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 388421

Carbohydrate Sulfotransferase 15/CHST15 Antibody - NBP1-88367 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Carbohydrate Sulfotransferase 15/CHST15 Antibody - NBP2-15896 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Carbohydrate Sulfotransferase 15/CHST15 Antibody - NBP1-59012 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHST15 antibody produced in rabbit - HPA017584 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHST15 antibody produced in rabbit - SAB2701480 from Sigma-Aldrich Prices $326.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-GALNAC4S-6ST antibody produced in rabbit - SAB2100888 from Sigma-Aldrich Prices $347.50, $347.50 Sizes 50 µg, 100 µl Host Rabbit Clonality Polyclonal

GALNAC4S-6ST antibody - middle region (ARP47193_P050) - ARP47193_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CHST15 antibody [N3C2], Internal - GTX120568 from GeneTex Prices $119.00 Sizes 25 μl Host Rabbit Clonality Polyclonal

Human Carbohydrate Sulfotransferase 15/CHST15 Antibody - MAB3365 from R&D Systems Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Mouse Clone 388421

Human CHST15 MAb (Clone 388421), Mouse IgG1 - MAB3365-SP from R&D Systems Host Mouse Clonality Monoclonal Clone 388421

Human Carbohydrate Sulfotransferase 15/CHST15 Antibody - AF3365 from R&D Systems Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat

Human CHST15 Affinity Purified Polyclonal Ab, Goat IgG - AF3365-SP from R&D Systems Host Goat Clonality Polyclonal

GALNAC4S-6ST antibody - 70R-5944 from Fitzgerald Host Rabbit Clonality Polyclonal

CHST15 antibody - 14298-1-AP from Acris Antibodies Prices $270.00 Sizes 150 µl Host Rabbit Clonality Polyclonal

GALNAC4S-6ST Antibody - 26-191 from ProSci Prices $315.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

CHST15 antibody - 14131-1-AP from Proteintech Group Host Rabbit Clonality Polyclonal

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