CHST15

Gene Symbol	CHST15
Entrez Gene	51363
Alt Symbol	BRAG, GALNAC4S-6ST
Species	Human
Gene Type	protein-coding
Description	carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
Other Description	B cell RAG associated protein (GALNAC4S-6ST)|B-cell RAG-associated gene protein|carbohydrate sulfotransferase 15|hBRAG
Swissprots	Q86VM4 O60474 O60338 Q7LFX5
Accessions	BAA83686 EAW49273 EAW49274 EAW49275 EAW49276 Q7LFX5 AB011170 BAA25524 AB062423 BAB72145 AF026477 AAC71691 AK294961 BAG58035 AK299546 BAG61492 BC027908 AAH27908 BC050540 AAH50540 BC075813 AAH75813 BM193389 BM977716 CR749804 CAH18664 XM_005269891 XP_005269948 XM_005269892 XP_005269949 XM_005269893 XP_005269950 XM_005269894 XP_005269951 XM_006717891 XP_006717954 XM_011539857 XP_011538159 XR_945773 NM_001270764 NP_001257693 NM_001270765 NP_001257694 NM_014863 NP_055678 NM_015892 NP_056976
Function	Sulfotransferase that transfers sulfate from 3'- phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non- reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B- cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo. {ECO:0000269|PubMed:11572857, ECO:0000269|PubMed:12874280}.
Subcellular Location	Golgi apparatus membrane {ECO:0000305|PubMed:10749872}; Single-pass type II membrane protein {ECO:0000305|PubMed:10749872}. Note=A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.
Tissue Specificity	Expressed in B-cell-enriched tissues but not in fetal or adult thymus. Expressed in fetal and adult spleen, lymph node, tonsil, bone marrow and peripheral leukocytes. Not expressed in T-cells. In pro-B, pre-B, and mature B-cell lines, it colocalizes with RAG1. {ECO:0000269|PubMed:9754571}.
Top Pathways	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ST4S6 full length protein - ab162523 from Abcam Category Protein Source Wheat germ Species Human

Carbohydrate Sulfotransferase 15/CHST15 Recombinant Protein - H00051363-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

CHST15-Antibody-C-term-Blocking-peptide - BP13376b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human CHST15, CF - 3365-ST-020 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser99-Thr561, with an N-terminal 6-His tag

Human BRAG His tag protein - orb83967 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 20 μg, 50 μg Source Human Species Human

GALNAC4S-6ST Blocking Peptide - 33R-10074 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CHST15 - H00051363-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

CHST15 fusion protein - Ag5679 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CHST15 fusion protein - Ag5901 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

CHST15 fusion protein - ag5258 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CHST15 fusion protein - Ag5805 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human CHST15, His tagged - CHST15-3197H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human CHST15, GST-tagged - CHST15-11228H from Creative Biomart Category Protein Source E.coli Species Human

BRAG - PN201314 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Human Cells Species Human

CHST15 / BRAG - PN201652 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Human Cells Species Human

Human CHST15 / GALNAC4S-6ST / BRAG Protein (His Tag) - 11033-H07H-20 from Sino Biological Category Protein Prices $178.00, $178.00 Sizes 20 µg, 50 µg Source Human Cells Species Human

Recombinant Human Carbohydrate sulfotransferase 15(CHST15) - CSB-YP748727HU CSB-EP748727HU CSB-BP748727HU CSB-MP748727HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human CHST15 Protein, CF - 3365-ST from R&D Systems Category Protein Prices $329.00 Sizes 20 µg Source Mouse myeloma cell line, NS0-derived Ser99-Thr561, with an N-terminal 6-His tag Species Human

CHST15 - TP306489 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Carbohydrate sulfotransferase 15 (CHST15), Recombinant Protein - MBS1455447 from MyBioSource Category Protein Prices $810.00, $810.00, $1,035.00, $1,035.00, $1,145.00, $1,145.00, $1,600.00, $1,600.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Carbohydrate sulfotransferase 15 (GALNAC4S6ST), Recombinant Protein - MBS1316391 from MyBioSource Category Protein Prices $900.00, $900.00, $1,125.00, $1,125.00, $1,330.00, $1,330.00, $1,785.00, $1,785.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Recombinant Human CHST15 / GALNAC4S-6ST / BRAG Protein (His tag) - PKSH031295 from Elabscience Category Protein Source Human Cells Species Human

Carbohydrate Sulfotransferase 15/CHST15 Recombinant Protein Antigen - NBP1-88367PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

CHST15 Peptide, Human - M34GP03150H from Creative Peptides Category Peptide Source Synthetic. Species Human

Human CHST15 / GALNAC4S-6ST / BRAG Protein (His Tag) - 11033-H07H from ABclonal Category Protein Prices $178.00, $298.00 Sizes 20 µg, 50 µg Source Human Cells Species Human

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