| Gene Symbol |
CHST15
|
| Entrez Gene |
51363
|
| Alt Symbol |
BRAG, GALNAC4S-6ST
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
|
| Other Description |
B cell RAG associated protein (GALNAC4S-6ST)|B-cell RAG-associated gene protein|carbohydrate sulfotransferase 15|hBRAG
|
| Swissprots |
Q86VM4 O60474 O60338 Q7LFX5
|
| Accessions |
BAA83686 EAW49273 EAW49274 EAW49275 EAW49276 Q7LFX5 AB011170 BAA25524 AB062423 BAB72145 AF026477 AAC71691 AK294961 BAG58035 AK299546 BAG61492 BC027908 AAH27908 BC050540 AAH50540 BC075813 AAH75813 BM193389 BM977716 CR749804 CAH18664 XM_005269891 XP_005269948 XM_005269892 XP_005269949 XM_005269893 XP_005269950 XM_005269894 XP_005269951 XM_006717891 XP_006717954 XM_011539857 XP_011538159 XR_945773 NM_001270764 NP_001257693 NM_001270765 NP_001257694 NM_014863 NP_055678 NM_015892 NP_056976
|
| Function |
Sulfotransferase that transfers sulfate from 3'- phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non- reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B- cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo. {ECO:0000269|PubMed:11572857, ECO:0000269|PubMed:12874280}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000305|PubMed:10749872}; Single-pass type II membrane protein {ECO:0000305|PubMed:10749872}. Note=A small fraction may also be present at the cell surface, where it acts as a B-cell receptor.
|
| Tissue Specificity |
Expressed in B-cell-enriched tissues but not in fetal or adult thymus. Expressed in fetal and adult spleen, lymph node, tonsil, bone marrow and peripheral leukocytes. Not expressed in T-cells. In pro-B, pre-B, and mature B-cell lines, it colocalizes with RAG1. {ECO:0000269|PubMed:9754571}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
|