Gene Symbol | TRPM7 |
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Entrez Gene | 54822 |
Alt Symbol | ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK |
Species | Human |
Gene Type | protein-coding |
Description | transient receptor potential cation channel, subfamily M, member 7 |
Other Description | LTRPC ion channel family member 7|channel-kinase 1|long transient receptor potential channel 7|transient receptor potential cation channel subfamily M member 7|transient receptor potential-phospholipase C-interacting kinase |
Swissprots | Q9NXQ2 Q8NBW2 Q96QT4 Q86VJ4 Q9BXB2 Q6ZMF5 |
Accessions | EAW77405 EAW77406 EAW77407 EAW77408 EAW77409 Q96QT4 AF346629 AAK19738 AK000124 BAA90958 AK075193 BAC11462 AK098584 AK172800 BAD18773 AY032950 AAK44211 BC028843 BC051024 AAH51024 BC128987 BC128988 BC169233 BC169234 BC169235 BP354541 DB127039 XM_005254486 XP_005254543 XM_005254487 XP_005254544 XM_011521712 XP_011520014 XR_931853 NM_001301212 NP_001288141 NM_017672 NP_060142 |
Function | Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). {ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:24316671}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Top Pathways | Mineral absorption |
Rat TRPM7 ELISA Kit (Sandwich ELISA) - LS-F7452 from LifeSpan Bioscience
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Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7), ELISA Kit - MBS2021989 from MyBioSource
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transient receptor potential cation channel, subfamily M, member 7, ELISA Kit - MBS9322665 from MyBioSource
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ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 7 (TRPM7) - SEF837Ra from Uscn Life Science Inc.
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Human TRPM7 ELISA Kit - E101367 from Biobool
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anti-TRPM7 / LTRPC7 antibody [S74-25] - ARG22280 from Arigo Biolaboratories
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anti-TRPM7 / LTRPC7 antibody - ARG63144 from Arigo Biolaboratories
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TRPM7 (Transient Receptor Potential Cation Channel Subfamily M, Member 7), ELISA Kit - MBS7606163 from MyBioSource
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Rat TRPM7 ELISA Kit (Sandwich ELISA) - LS-F32228 from LifeSpan Bioscience
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