| Gene Symbol |
TRPM7
|
| Entrez Gene |
54822
|
| Alt Symbol |
ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily M, member 7
|
| Other Description |
LTRPC ion channel family member 7|channel-kinase 1|long transient receptor potential channel 7|transient receptor potential cation channel subfamily M member 7|transient receptor potential-phospholipase C-interacting kinase
|
| Swissprots |
Q9NXQ2 Q8NBW2 Q96QT4 Q86VJ4 Q9BXB2 Q6ZMF5
|
| Accessions |
EAW77405 EAW77406 EAW77407 EAW77408 EAW77409 Q96QT4 AF346629 AAK19738 AK000124 BAA90958 AK075193 BAC11462 AK098584 AK172800 BAD18773 AY032950 AAK44211 BC028843 BC051024 AAH51024 BC128987 BC128988 BC169233 BC169234 BC169235 BP354541 DB127039 XM_005254486 XP_005254543 XM_005254487 XP_005254544 XM_011521712 XP_011520014 XR_931853 NM_001301212 NP_001288141 NM_017672 NP_060142
|
| Function |
Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). {ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:24316671}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Top Pathways |
Mineral absorption
|