TRPM7

Gene Symbol TRPM7
Entrez Gene 54822
Alt Symbol ALSPDC, CHAK, CHAK1, LTRPC7, LTrpC-7, TRP-PLIK
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily M, member 7
Other Description LTRPC ion channel family member 7|channel-kinase 1|long transient receptor potential channel 7|transient receptor potential cation channel subfamily M member 7|transient receptor potential-phospholipase C-interacting kinase
Swissprots Q9NXQ2 Q8NBW2 Q96QT4 Q86VJ4 Q9BXB2 Q6ZMF5
Accessions EAW77405 EAW77406 EAW77407 EAW77408 EAW77409 Q96QT4 AF346629 AAK19738 AK000124 BAA90958 AK075193 BAC11462 AK098584 AK172800 BAD18773 AY032950 AAK44211 BC028843 BC051024 AAH51024 BC128987 BC128988 BC169233 BC169234 BC169235 BP354541 DB127039 XM_005254486 XP_005254543 XM_005254487 XP_005254544 XM_011521712 XP_011520014 XR_931853 NM_001301212 NP_001288141 NM_017672 NP_060142
Function Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). {ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:24316671}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Top Pathways Mineral absorption

LTRPC7 (H-4) - sc-271099 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
LTRPC7 (H-4): sc-271099. Western blot analysis of LTRPC7 expression in HeLa (A) and Daudi (B) whole cell lysates.

LTRPC7 (L-18) - sc-31381 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LTRPC7 (L-18): sc-31381. Western blot analysis of LTRPC7 expression in A549 (A) and HEK293 (B) whole cell lysates.

LTRPC7 (G-16) - sc-31379 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LTRPC7 (H-300) - sc-98250 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
LTRPC7 (H-300): sc-98250. Western blot analysis of LTRPC7 expression in HeLa whole cell lysate.

LTRPC7 (H-15) - sc-31378 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

LTRPC7 (K-20) - sc-19563 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LTRPC7 (K-20): sc-19563. Immunoperoxidase staining of formalin fixed, paraffin-embedded human liver tissue showing cytoplasmic staining of hepatocytes.

LTRPC7 (N-17) - sc-19562 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
LTRPC7 (N-17): sc-19562. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing membrane localization.

Anti-TRPM7 antibody - ab729 from Abcam

Prices $379.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-TRPM7 antibody - ab72155 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-TRPM7 antibody (ab72155) at 1/200 dilutionLane 1 : Human neutrophil lysateLane 2 : Immunising peptide

Anti-TRPM7 antibody - ab63088 from Abcam

Host Rabbit
Clonality Polyclonal
ICC/IF image of ab63088 stained HeLa cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab63088, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h.Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-TRPM7 antibody - ab79771 from Abcam

Host Sheep
Clonality Polyclonal

Anti-TRPM7 antibody - ab62989 from Abcam

Host Sheep
Clonality Polyclonal

Anti-TRPM7 antibody [EPR4582] - ab109438 from Abcam

Prices $99.00, $379.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR4582
All lanes : Anti-TRPM7 antibody [EPR4582] (ab109438) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : HuT-78 cell lysateLane 3 : JAR cell lysateLane 4 : HepG2 cell lysateLysates/proteins at 10 µg per lane.

Anti-TRPM7 antibody [S74-25] - ab85016 from Abcam

Prices $390.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S74-25
ab85016 staining TRPM7 in cultured mouse urothelial cells by Immunocytochemistry. Note that TRPM7 (green) is present in the plasma membrane as well as cytoplasmic vesicles. Nuclei stained blue with DAPI.Urothelial cells from mice were fixed with 3.7% formaldehyde for 10 minutes, permeabilized with 0.2% Triton X-100 for 10 minutes, and blocked with 3% BSA for 3 hours. The primary antibody was used at a 1/400 dilution and incubated overnight. The secondary antibody was an Alexa Fluor488-conjugated anti-rabbit IgG, used at a 1/1000 dilution, applied for 1 hour at room temperature. Triple washing with PBS was performed between each step.

Anti-TRPM7 antibody - C-terminal - ab135817 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-TRPM7 antibody - C-terminal (ab135817) at 1/50 dilution + 293 cell line lysates at 35 µg

Anti-TRPM7 Antibody (aa1817-1863, clone S74-25, Atto 594) - LS-C230773 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S74-25

Anti-TRPM7 Antibody (aa1817-1863, clone S74-25, Atto 633) - LS-C230774 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S74-25

Anti-TRPM7 Antibody (C-Terminus) IHC-plus™ - LS-B7267 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Anti-TRPM7 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7267 concentration 10 ug/ml.

Anti-TRPM7 Antibody (aa1817-1863, clone S74-25, Atto 680) - LS-C230775 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S74-25

Anti-TRPM7 Antibody (aa1817-1863, clone S74-25, Atto 700) - LS-C230776 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S74-25

Anti-TRPM7 Antibody (aa1817-1863, clone S74-25, AP) - LS-C230778 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S74-25

Anti-TRPM7 Antibody (aa1817-1863, clone S74-25, Atto 655) - LS-C230777 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S74-25

Anti-TRPM7 Antibody (aa1817-1863, clone S74-25, APC) - LS-C230780 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S74-25

Anti-TRPM7 Antibody (aa1817-1863, clone S74-25, Biotin) - LS-C230779 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S74-25

Anti-TRPM7 Antibody (aa1817-1863, clone S74-25, Atto 390) - LS-C230783 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S74-25
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