ICOSLG

Gene Symbol	ICOSLG
Entrez Gene	23308
Alt Symbol	B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS
Species	Human
Gene Type	protein-coding
Description	inducible T-cell co-stimulator ligand
Other Description	B7 homolog 2|B7 homologue 2|B7-like protein Gl50|B7-related protein 1|ICOS ligand|transmembrane protein B7-H2 ICOS ligand
Swissprots	Q9HD18 A8MUZ1 O75144 Q9NRQ1
Accessions	ABK41909 CAC36465 CAX87084 EAX09446 EAX09447 EAX09448 O75144 AA781960 AB014553 BAA31628 AF199028 AAF34739 AF216749 AAK16241 AF289028 AAG01176 AI659611 AK090492 BAG52170 AK290192 BAF82881 AK294031 BAH11654 AK311496 AK314369 BAG36999 AK316143 BAH14514 AK316176 BAH14547 AL355690 BC064637 AAH64637 BQ005303 DC365972 HQ448129 ADQ32610 XM_011529514 XP_011527816 XM_011529515 XP_011527817 XM_011529516 XP_011527818 NM_001283050 NP_001269979 NM_001283051 NP_001269980 NM_001283052 NP_001269981 NM_015259 NP_056074
Function	Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity). {ECO:0000250}.
Subcellular Location	Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity	Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. {ECO:0000269|PubMed:10779774}.
Top Pathways	Cell adhesion molecules (CAMs), Intestinal immune network for IgA production

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

B7RP-1 (FL-302) - sc-25586 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

B7RP-1 (F-15) - sc-14596 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

B7RP-1 (K-16) - sc-14597 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-ICOS Ligand antibody - ab88343 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ICOS Ligand antibody - ab123554 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ICOS Ligand antibody [2D3] - ab189052 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2D3

Anti-ICOS Ligand antibody [EPR6071] - ab124972 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR6071

Anti-ICOS Ligand antibody [GM-13C1] - ab3774 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone GM-13C1

Anti-ICOS Ligand antibody - N-terminal - ab135310 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ICOS Ligand antibody - N-terminal - ab200461 from Abcam Host Rabbit Clonality Polyclonal

Anti-CD275 / B7-H2 / ICOS Ligand Antibody (Extracellular Domain) - LS-C15852 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Monoclonal

Anti-CD275 / B7-H2 / ICOS Ligand Antibody (Extracellular Domain) - LS-C15851 from LifeSpan Bioscience Prices $590.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-CD275 / B7-H2 / ICOS Ligand Antibody - LS-C36841 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-CD275 / B7-H2 / ICOS Ligand Antibody (aa216-246) - LS-C329660 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CD275 / B7-H2 / ICOS Ligand Antibody (aa20-303) - LS-C308373 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-CD275 / B7-H2 / ICOS Ligand Antibody (aa217-246) - LS-C165109 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-CD275 / B7-H2 / ICOS Ligand Antibody (aa23-249) - LS-C294599 from LifeSpan Bioscience Prices $375.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CD275 / B7-H2 / ICOS Ligand Antibody (aa58-249) - LS-C314619 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CD275 / B7-H2 / ICOS Ligand Antibody (clone 2D3) IHC-plus™ - LS-B2001 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 2D3

Anti-CD275 / B7-H2 / ICOS Ligand Antibody - LS-C68332 from LifeSpan Bioscience Prices $575.00 Sizes 500 µg Host Mouse Clonality Monoclonal

Anti-CD275 / B7-H2 / ICOS Ligand Antibody - LS-C68335 from LifeSpan Bioscience Prices $620.00 Sizes 500 µg Host Mouse Clonality Monoclonal

Anti-ICOSLG / ICOSL / ICOS Ligand Antibody - LS-C92660 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-CD275 / B7-H2 / ICOS Ligand Antibody (PE) - LS-C92661 from LifeSpan Bioscience Prices $455.00 Sizes 100 tst Host Mouse Clonality Monoclonal

Anti-CD275 / B7-H2 / ICOS Ligand Antibody (clone 9F.8A4) - LS-C40799 from LifeSpan Bioscience Prices $225.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 9F.8A4

Anti-CD275 / B7-H2 / ICOS Ligand Antibody - LS-C123802 from LifeSpan Bioscience Prices $515.00 Sizes 200 µg Host Mouse Clonality Monoclonal

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