ICOSLG

Gene Symbol	ICOSLG
Entrez Gene	23308
Alt Symbol	B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS
Species	Human
Gene Type	protein-coding
Description	inducible T-cell co-stimulator ligand
Other Description	B7 homolog 2|B7 homologue 2|B7-like protein Gl50|B7-related protein 1|ICOS ligand|transmembrane protein B7-H2 ICOS ligand
Swissprots	Q9HD18 A8MUZ1 O75144 Q9NRQ1
Accessions	ABK41909 CAC36465 CAX87084 EAX09446 EAX09447 EAX09448 O75144 AA781960 AB014553 BAA31628 AF199028 AAF34739 AF216749 AAK16241 AF289028 AAG01176 AI659611 AK090492 BAG52170 AK290192 BAF82881 AK294031 BAH11654 AK311496 AK314369 BAG36999 AK316143 BAH14514 AK316176 BAH14547 AL355690 BC064637 AAH64637 BQ005303 DC365972 HQ448129 ADQ32610 XM_011529514 XP_011527816 XM_011529515 XP_011527817 XM_011529516 XP_011527818 NM_001283050 NP_001269979 NM_001283051 NP_001269980 NM_001283052 NP_001269981 NM_015259 NP_056074
Function	Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity). {ECO:0000250}.
Subcellular Location	Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity	Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. {ECO:0000269|PubMed:10779774}.
Top Pathways	Cell adhesion molecules (CAMs), Intestinal immune network for IgA production

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ICOSLG-Over-expression-Lysate - LY15828a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

B7RP-1 (h): 293T Lysate - sc-116982 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

Cynomolgus ICOS Ligand / B7-H2 / ICOSLG HEK293 Cell Lysate (WB positive control) - 90800-C08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human ICOS Ligand / B7-H2 / ICOSLG HEK293 Cell Lysate (WB positive control) - 11559-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

B7-H2/ICOSLG Overexpression Lysate (Native) - NBP2-04349 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Human ICOSLG Human Cells Transfected Lysate (positive control) (denatured) - orb174574 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human ICOSLG Knockdown Stable Cell Line - CSC-DC007390 from Creative biogene Category Cell Line Species Human

ICOSLG Knockout Cell Line-HeLa - CSC-RT1961 from Creative biogene Category Cell Line Species Human

ICOSLG KO Cell Lysate-HeLa - CLKO-1820 from Creative biogene Category Cell Lysate

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