ICOSLG

Gene Symbol	ICOSLG
Entrez Gene	23308
Alt Symbol	B7-H2, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, LICOS
Species	Human
Gene Type	protein-coding
Description	inducible T-cell co-stimulator ligand
Other Description	B7 homolog 2|B7 homologue 2|B7-like protein Gl50|B7-related protein 1|ICOS ligand|transmembrane protein B7-H2 ICOS ligand
Swissprots	Q9HD18 A8MUZ1 O75144 Q9NRQ1
Accessions	ABK41909 CAC36465 CAX87084 EAX09446 EAX09447 EAX09448 O75144 AA781960 AB014553 BAA31628 AF199028 AAF34739 AF216749 AAK16241 AF289028 AAG01176 AI659611 AK090492 BAG52170 AK290192 BAF82881 AK294031 BAH11654 AK311496 AK314369 BAG36999 AK316143 BAH14514 AK316176 BAH14547 AL355690 BC064637 AAH64637 BQ005303 DC365972 HQ448129 ADQ32610 XM_011529514 XP_011527816 XM_011529515 XP_011527817 XM_011529516 XP_011527818 NM_001283050 NP_001269979 NM_001283051 NP_001269980 NM_001283052 NP_001269981 NM_015259 NP_056074
Function	Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function (By similarity). {ECO:0000250}.
Subcellular Location	Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity	Isoform 1 is widely expressed (brain, heart, kidney, liver, lung, pancreas, placenta, skeletal muscle, bone marrow, colon, ovary, prostate, testis, lymph nodes, leukocytes, spleen, thymus and tonsil), while isoform 2 is detected only in lymph nodes, leukocytes and spleen. Expressed on activated monocytes and dendritic cells. {ECO:0000269|PubMed:10779774}.
Top Pathways	Cell adhesion molecules (CAMs), Intestinal immune network for IgA production

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD275 / B7-H2 / ICOS Ligand ELISA Kit (Sandwich ELISA) - LS-F9059 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Human ICOSLG ELISA Kit - abx151896 from Abbexa Category ELISA Kit Sensitivity 0.063 ng/ml Range 0.156 ng/ml - 10 ng/ml

ICOS ligand (ICOSLG), Human, ELISA Kit - CSB-EL010958HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 23.4 pg/ml Range 93.75 pg/ml-6000 pg/ml

Inducible T-Cell Co Stimulator Ligand (ICOSLG), Human, ELISA Kit - SEA787Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.057ng/mL Range 0.156-10ng/mL

ICOSLG (Human) Matched Antibody Pair - H00023308-AP11 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

ICOSLG (Human) Matched Antibody Pair - H00023308-AP12 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

ICOSLG (Human) Matched Antibody Pair - H00023308-AP41 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Custom Human B7-H2 ELISA - ELH-B7H2 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

ICOSL, ELISA Kit - MBS2516282 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.875pg/mL Range 78.125-5000pg/mL

inducible T-cell co-stimulator ligand, ELISA Kit - MBS927767 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of human ICOSLG is typically less than 23.4 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 93.75 pg/ml - 6000 pg/ml.

ELISA Kit for Inducible T-Cell Co Stimulator Ligand (ICOSLG) - SEA787Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human ICOS ligand(ICOSLG) ELISA kit - CSB-EL010958HU from Cusabio Category ELISA Kit Sensitivity 23.4pg/ml Range 93.75 pg/ml-6000 pg/ml

ELISA Kit for Inducible T-Cell Co Stimulator Ligand (ICOSLG) - SEA787Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human CD275 / B7-H2 / ICOS Ligand ELISA Kit (Custom ELISA) - LS-F17820 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Mouse CD275 / B7-H2 / ICOS Ligand ELISA Kit (Custom ELISA) - LS-F17819 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.156-10 ng/ml

Inducible T-Cell Co Stimulator Ligand (ICOSLG), Human, ELISA Kit - DL-ICOSLG-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human ICOS Ligand/B7-H2/ICOSLG ELISA Kit - NS-E10205 from Novatein Biosciences Category ELISA Kit Prices $459.00 Sizes 96 t Sensitivity 50 pg/mL Range 62.5 - 4000 pg/ml

Human ICOS Ligand ELISA Pair Set - orb172744 from Biorbyt Category ELISA Kit Prices $510.00, $1,148.00 Sizes 5 plates, 15 plates Sensitivity 62.5 pg/ml

Human ICOSLG ELISA Kit - abx571653 from Abbexa Category ELISA Kit Sensitivity 0.057 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human ICOS Ligand / B7-H2 / ICOSLG ELISA Pair Set - SEK11559-15 from Sino Biological Category ELISA Kit Prices $249.00, $249.00 Sizes 5 plates, 15 plates

Human B7-H2 ELISA - RAB1281 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

Human ICOS ligand(ICOSLG) ELISA Kit - EKC34097 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,287.50 Sizes 96 t, 5x96t, 10x96t Sensitivity 23.4pg/ml Range 93.75 pg/ml-6000 pg/ml

Human B7-H2/ICOS Ligand ELISA - ELH-B7H2-1 from RayBiotech Category ELISA Kit Prices $417.00, $750.60, $1,668.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human ICOSLG ELISA Kit - E019719 from Biobool Category ELISA Kit Sensitivity Typically less than 0.063ng/mL.

ICOS ligand, ELISA Kit - MBS2881865 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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